Objective: Recent studies have demonstrated the importance of Endoplasmic Reticulum
Aminopeptidase 1 (ERAP1) gene variants in inflammatory conditions, including Type 1 diabetes mellitus.
However, to date, no large prospective, genetic-epidemiological data are available on the relevance
of ERAP1 genetic variation in the risk of non-insulin dependent diabetes.
Methods: The association between 33 tag-SNPs (tSNPs) of ERAP1 and incident Type 2 Diabetes mellitus
(T2D) was investigated in 22,718 Caucasian female participants of the prospective Women's Genome
Health Study. All were free of known cancer, cardiovascular disease, and diabetes mellitus at
baseline. During an 18-year follow-up period, 1,927 newly diagnosed first ever T2D were identified.
Multivariable Cox regression analysis was performed to investigate the relationship between genotypes
and T2D risk assuming an additive genetic model.
Results: None of the gene variants evaluated were associated with T2D risk.
Conclusions: If corroborated in other large prospective studies, the present findings suggest that genetic
variation within the ERAP1 gene locus may not be useful prognostic indicators for risk assessment of
type 2 diabetes mellitus.