Self-Assembled Nanocarriers Based on Amphiphilic Natural Polymers for Anti- Cancer Drug Delivery Applications

Author(s): Sally Sabra, Mona Abdelmoneem, Mahmoud Abdelwakil, Moustafa Taha Mabrouk, Doaa Anwar, Rania Mohamed, Sherine Khattab, Adnan Bekhit, Kadria Elkhodairy, May Freag, Ahmed Elzoghby*

Journal Name: Current Pharmaceutical Design

Volume 23 , Issue 35 , 2017


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Abstract:

Background: Micellization provides numerous merits for the delivery of water insoluble anti-cancer therapeutic agents including a nanosized ‘core–shell' drug delivery system. Recently, hydrophobically-modified polysaccharides and proteins are attracting much attention as micelle forming polymers to entrap poorly soluble anti-cancer drugs.

Method: By virtue of their small size, the self-assembled micelles can passively target tumor tissues via enhanced permeation and retention effect (EPR). Moreover, the amphiphilic micelles can be exploited for active-targeted drug delivery by attaching specific targeting ligands to the outer micellar hydrophilic surface.

Results: Here, we review the conjugation techniques, drug loading methods, physicochemical characteristics of the most important amphiphilic polysaccharides and proteins used as anti-cancer drug delivery systems. Attention focuses on the mechanisms of tumor-targeting and enhanced anti-tumor efficacy of the encapsulated drugs. This review will highlight the remarkable advances of hydrophobized polysaccharide and protein micelles and their potential applications as anti-cancer drug delivery nanosystems.

Conclusion: Micellar nanocarriers fabricated from amphiphilic natural polymers hold great promise as vehicles for anti-cancer drugs.

Keywords: Amphiphilic polymers, self-assembled micelles, polysaccharides, proteins, anti-cancer drugs, tumor-targeting.

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Article Details

VOLUME: 23
ISSUE: 35
Year: 2017
Published on: 30 January, 2018
Page: [5213 - 5229]
Pages: 17
DOI: 10.2174/1381612823666170526111029
Price: $65

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