Recent Advances in Synthesis of Functionalized β-Lactams through Cyclization of N-Propargyl Amine/Amide Derivatives

Author(s): Esmail Vessally*, Mirzaagha Babazadeh, Akram Hosseinian, Ladan Edjlali*, Lakshmaiah Sreerama*

Journal Name: Current Organic Chemistry

Volume 22 , Issue 2 , 2018

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Graphical Abstract:


β-lactams have attracted a significant attention due to their potential biological activities and wide variety of synthetic applications. Developing novel and efficient methods for construction of functionalized β-lactams has been the subject of a number of papers in recent years. N-Propargyl amines/amides are one of the most specific class of alkynes having diverse reaction patterns. It is well known that they can undergo a number of cyclization reactions to produce various significant nitrogen containing heterocycles. This review surveys literature methods for the synthesis of highly substituted β-lactams from simple and easily available N-propargyl amine/amide derivatives from 1991 to 2017.

Keywords: β-lactams, N-propargylamines, N-propargylamides, 4-exo-dig cyclization, Ugi-adducts, carbon monoxide.

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Article Details

Year: 2018
Published on: 19 March, 2018
Page: [199 - 205]
Pages: 7
DOI: 10.2174/1385272821666170519113904
Price: $58

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