Synthetic Approaches to Various Class of Topoisomerase II Inhibitors

Author(s): Sanal Dev*, Nishad Gabhe, S.R. Dhaneshwar, Monu Joy, Bijo Mathew

Journal Name: Mini-Reviews in Organic Chemistry

Volume 14 , Issue 5 , 2017

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Abstract:

Considering the diverse applications and importance of DNA topoisomerases II (TOP II) inhibitors in biological systems, it is vital to understand the fundamental organic chemistry of these inhibitory agents through various synthetic strategies and it is crucial for further developments of the same. Many of the reported TOP II inhibitors are associated with extreme structural complexities and require multi-step synthetic routes providing difficulties towards their preparation and modifications. The present work describes the synthetic protocols for a diverse array of candidates relating to both TOP II poisons and catalytic inhibitors which may be useful for further synthetic developments.

Keywords: Topoisomerase II, etoposide, mitoxantrone, pharmacophoresm, podophyllotoxin, antineoplastic agent.

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Article Details

VOLUME: 14
ISSUE: 5
Year: 2017
Page: [357 - 374]
Pages: 18
DOI: 10.2174/1570193X14666170518130301
Price: $65

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