2,3-Dichloro-1,4-naphthoquinone is a special naphthoquinone with four electrophilic sites, useful for
applications in organic synthesis and preparation of a diverse new compounds, such as 2,3-substituted derivatives
and heterocycles, including those with the core naphthoquinone structure fused. It has also been used for
the preparation of compounds for evaluation against several biological targets. This review will describe the
most recent applications of 2,3-dichloro-1,4-naphthoquinone in organic synthesis.