Thioureas as Building Blocks for the Generation of Heterocycles and Compounds with Pharmacological Activity: An Overview

Author(s): Itamar Luís Goncalves, Gabriel Oliveira de Azambuja, Daniel Fabio Kawano, Vera Lucia Eifler-Lima*

Journal Name: Mini-Reviews in Organic Chemistry

Volume 15 , Issue 1 , 2018

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Graphical Abstract:


Background: Thioureas are widely used as intermediates in organic synthesis, and they are commonly used in several classes of heterocycles.

Objective: There has been an escalating interest in the development of heterocycles employing thioureas as building blocks. Furthermore, thioureas can be utilized as a reagent in a synthesis of a large number of therapeutic agents. In addition, substituted thioureas have recently gained much interest in the preparation of a wide variety of biologically active compounds.

Conclusion: This review highlights the status of thiourea scaffolds in the drug development and heterocyclic synthesis described in the literature mainly since 2010.

Keywords: Thiourea, heterocyclic synthesis, building blocks, drug design, pharmacological effects, multicomponent reactions.

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Article Details

Year: 2018
Published on: 29 January, 2018
Page: [28 - 35]
Pages: 8
DOI: 10.2174/1570193X14666170518125219
Price: $65

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PDF: 34
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