Title:Thioureas as Building Blocks for the Generation of Heterocycles and Compounds with Pharmacological Activity: An Overview
VOLUME: 15 ISSUE: 1
Author(s):Itamar Luís Goncalves, Gabriel Oliveira de Azambuja, Daniel Fabio Kawano and Vera Lucia Eifler-Lima*
Affiliation:Laboratorio de Sintese Organica Medicinal/LaSOM, Programa de Pos-Graduacao em Ciencias Farmaceuticas/ PPGCF, Universidade Federal do Rio Grande do Sul, Av. Ipiranga 2752, 90610-000 Porto Alegre-RS, Laboratorio de Sintese Organica Medicinal/LaSOM, Programa de Pos-Graduacao em Ciencias Farmaceuticas/ PPGCF, Universidade Federal do Rio Grande do Sul, Av. Ipiranga 2752, 90610-000 Porto Alegre-RS, Faculdade de Ciencias Farmaceuticas, Universidade Estadual de Campinas, Rua Sergio Buarque de Holanda 250, 13083-859 Campinas-SP, Laboratorio de Sintese Organica Medicinal/LaSOM, Programa de Pos-Graduacao em Ciencias Farmaceuticas/ PPGCF, Universidade Federal do Rio Grande do Sul, Av. Ipiranga 2752, 90610-000 Porto Alegre-RS
Keywords:Thiourea, heterocyclic synthesis, building blocks, drug design, pharmacological effects, multicomponent reactions.
Abstract:Background: Thioureas are widely used as intermediates in organic synthesis, and they are
commonly used in several classes of heterocycles.
Objective: There has been an escalating interest in the development of heterocycles employing thioureas
as building blocks. Furthermore, thioureas can be utilized as a reagent in a synthesis of a large number
of therapeutic agents. In addition, substituted thioureas have recently gained much interest in the preparation
of a wide variety of biologically active compounds.
Conclusion: This review highlights the status of thiourea scaffolds in the drug development and heterocyclic
synthesis described in the literature mainly since 2010.
