Background: The Diels-Alder reaction is one of the most important reactions in organic synthesis.
Objective: Recently there has been considerable interest in conducting this important reaction in aqueous
or semi-aqueous media using organocatalysts due to the green nature of the water solvent and organocatalysts
as well as the special solvent effects of water on organic reactions.
Conclusion: This review attempts to summarize the most recent developments in organocatalytic
asymmetric Diels-Alder reactions using water as a solvent or a co-solvent.
Keywords: Diels-Alder reaction, organocatalysis, asymmetric, water, renewable solvent, green chemistry, semi-aqueous media.
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