Flavonoids as Multi-Target Compounds in Drug Discovery

Author(s): L. Scotti*, H. Ishiki, F.J.B. Mendonça Júnior, R.M.D. Cruz, J.F. Tavares, M.F.F.M. Diniz, J.M. Barbosa Filho, M.T. Scotti

Journal Name: Mini-Reviews in Organic Chemistry

Volume 14 , Issue 4 , 2017

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Graphical Abstract:


With the aim of offering patients a more effective drug therapy and with few side effects, it was believed in the perfect and unique interaction of the bioactive compound and the receptor or target macromolecule. This concept has changed, and multifunctional compounds show greater efficiency, particularly in the therapy of complex diseases, with a sum of origin. Among these ills, we quote: neurodegenerative diseases, cancer, parasitic and inflammatory. To fight these diseases, studies with multitarget flavonoids have been reported. Flavonoid compounds are natural products traditionally used as chemotherapy because of their numerous therapeutic activities. Here, we gather studies with multitarget in drug discovery flavonoids.

Keywords: Flavonoids, multi-target, drug, neurodegenerative, cancer, parasite, inflammation.

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Article Details

Year: 2017
Page: [333 - 341]
Pages: 9
DOI: 10.2174/1570193X14666170518112248
Price: $65

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