Effects of Diets on Adipose Tissue

Author(s): Silvia Ezquerro, Amaia Rodríguez, Piero Portincasa, Gema Frühbeck*

Journal Name: Current Medicinal Chemistry

Volume 26 , Issue 19 , 2019

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Background: Obesity is a major health problem that has become a global epidemic. Overweight and obesity are commonly associated with the development of several pathologies, such as insulin resistance, cardiovascular diseases, sleep apnea and several types of cancer, which can lead to further morbidity and mortality. An increased abdominal adiposity renders overweight and obese individuals more prone to metabolic and cardiovascular problems.

Objective: This Review aims to describe the dietary strategies to deal with excess adiposity given the medical, social and economic consequences of obesity.

Methods: One hundred and eighty-five papers were included in the present Review.

Results: Excess adiposity leads to several changes in the biology, morphology and function of the adipose tissue, such as adipocyte hypertrophy and hyperplasia, adipose tissue inflammation and fibrosis and an impaired secretion of adipokines, contributing to the onset of obesity- related comorbidities. The first approach for obesity management and prevention is the implementation of a diet combined with physical activity. The present review summarizes the compelling evidence showing body composition changes, impact on cardiometabolism and potential adverse effects of very-low calorie, low- and high-carbohydrate, high-protein or low-fat diets. The use of macronutrients during the preprandial and postprandial state has been also reviewed to better understand the metabolic changes induced by different dietary interventions.

Conclusion: Dietary changes should be individualised, tailored to food preferences and allow for flexible approaches to reducing calorie intake in order to increase the motivation and compliance of overweight and obese patients.

Keywords: Excess adiposity, very-low calorie diets, high-protein diets, low and high-carbohydrate diets, low fat diets, glucose metabolism.

Frühbeck, G.; Toplak, H.; Woodward, E.; Yumuk, V.; Maislos, M.; Oppert, J.M. Obesity: the gateway to ill health - an EASO position statement on a rising public health, clinical and scientific challenge in Europe. Obes. Facts, 2013, 6(2), 117-120.
[http://dx.doi.org/10.1159/000350627] [PMID: 23548858]
Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19·2 million participants. Lancet, 2016, 387(10026), 1377-1396.
[http://dx.doi.org/10.1016/S0140-6736(16)30054-X] [PMID: 27115820]
Rodríguez, A.; Catalán, V.; Gómez-Ambrosi, J.; Frühbeck, G. Visceral and subcutaneous adiposity: are both potential therapeutic targets for tackling the metabolic syndrome? Curr. Pharm. Des., 2007, 13(21), 2169-2175.
[http://dx.doi.org/10.2174/138161207781039599] [PMID: 17627548]
Fuster, J.J.; Ouchi, N.; Gokce, N.; Walsh, K. Obesity-induced changes in adipose tissue microenvironment and their impact on cardiovascular disease. Circ. Res., 2016, 118(11), 1786-1807.
[http://dx.doi.org/10.1161/CIRCRESAHA.115.306885] [PMID: 27230642]
Rodríguez, A.; Ezquerro, S.; Méndez-Giménez, L.; Becerril, S.; Frühbeck, G. Revisiting the adipocyte: a model for integration of cytokine signaling in the regulation of energy metabolism. Am. J. Physiol. Endocrinol. Metab., 2015, 309(8), E691-E714.
[http://dx.doi.org/10.1152/ajpendo.00297.2015] [PMID: 26330344]
Frühbeck, G.; Toplak, H.; Woodward, E.; Halford, J.C.; Yumuk, V. Need for a paradigm shift in adult overweight and obesity management - an EASO position statement on a pressing public health, clinical and scientific challenge in Europe. Obes. Facts, 2014, 7(6), 408-416.
[http://dx.doi.org/10.1159/000370038] [PMID: 25503968]
Rubino, F.; Nathan, D.M.; Eckel, R.H.; Schauer, P.R.; Alberti, K.G.; Zimmet, P.Z.; Del Prato, S.; Ji, L.; Sadikot, S.M.; Herman, W.H.; Amiel, S.A.; Kaplan, L.M.; Taroncher-Oldenburg, G.; Cummings, D.E. Metabolic Surgery in the Treatment Algorithm for Type 2 Diabetes: A Joint Statement by International Diabetes Organizations. Diabetes Care, 2016, 39(6), 861-877.
[http://dx.doi.org/10.2337/dc16-0236] [PMID: 27222544]
Janssen, I.; Mark, A.E. Elevated body mass index and mortality risk in the elderly. Obes. Rev., 2007, 8(1), 41-59.
[http://dx.doi.org/10.1111/j.1467-789X.2006.00248.x] [PMID: 17212795]
Gómez-Ambrosi, J.; Silva, C.; Galofré, J.C.; Escalada, J.; Santos, S.; Millán, D.; Vila, N.; Ibañez, P.; Gil, M.J.; Valentí, V.; Rotellar, F.; Ramírez, B.; Salvador, J.; Frühbeck, G. Body mass index classification misses subjects with increased cardiometabolic risk factors related to elevated adiposity. Int. J. Obes., 2012, 36(2), 286-294.
[http://dx.doi.org/10.1038/ijo.2011.100] [PMID: 21587201]
Blundell, J.E.; Dulloo, A.G.; Salvador, J.; Frühbeck, G. Beyond BMI--phenotyping the obesities. Obes. Facts, 2014, 7(5), 322-328.
[http://dx.doi.org/10.1159/000368783] [PMID: 25485991]
Gallagher, D.; Heymsfield, S.B.; Heo, M.; Jebb, S.A.; Murgatroyd, P.R.; Sakamoto, Y. Healthy percentage body fat ranges: an approach for developing guidelines based on body mass index. Am. J. Clin. Nutr., 2000, 72(3), 694-701.
[http://dx.doi.org/10.1093/ajcn/72.3.694] [PMID: 10966886]
Gómez-Ambrosi, J.; Silva, C.; Galofré, J.C.; Escalada, J.; Santos, S.; Gil, M.J.; Valentí, V.; Rotellar, F.; Ramírez, B.; Salvador, J.; Frühbeck, G. Body adiposity and type 2 diabetes: increased risk with a high body fat percentage even having a normal BMI. Obesity (Silver Spring), 2011, 19(7), 1439-1444.
[http://dx.doi.org/10.1038/oby.2011.36] [PMID: 21394093]
Bray, G.A.; Frühbeck, G.; Ryan, D.H.; Wilding, J.P. Management of obesity. Lancet, 2016, 387(10031), 1947-1956.
[http://dx.doi.org/10.1016/S0140-6736(16)00271-3] [PMID: 26868660]
Lichtenstein, A.H.; Appel, L.J.; Brands, M.; Carnethon, M.; Daniels, S.; Franch, H.A.; Franklin, B.; Kris-Etherton, P.; Harris, W.S.; Howard, B.; Karanja, N.; Lefevre, M.; Rudel, L.; Sacks, F.; Van Horn, L.; Winston, M.; Wylie-Rosett, J. Diet and lifestyle recommendations revision 2006: a scientific statement from the American Heart Association Nutrition Committee. Circulation, 2006, 114(1), 82-96.
[http://dx.doi.org/10.1161/CIRCULATIONAHA.106.176158] [PMID: 16785338]
Jensen, M.D.; Ryan, D.H.; Apovian, C.M.; Ard, J.D.; Comuzzie, A.G.; Donato, K.A.; Hu, F.B.; Hubbard, V.S.; Jakicic, J.M.; Kushner, R.F.; Loria, C.M.; Millen, B.E.; Nonas, C.A.; Pi-Sunyer, F.X.; Stevens, J.; Stevens, V.J.; Wadden, T.A.; Wolfe, B.M.; Yanovski, S.Z.; Jordan, H.S.; Kendall, K.A.; Lux, L.J.; Mentor-Marcel, R.; Morgan, L.C.; Trisolini, M.G.; Wnek, J.; Anderson, J.L.; Halperin, J.L.; Albert, N.M.; Bozkurt, B.; Brindis, R.G.; Curtis, L.H.; DeMets, D.; Hochman, J.S.; Kovacs, R.J.; Ohman, E.M.; Pressler, S.J.; Sellke, F.W.; Shen, W.K.; Smith, S.C., Jr; Tomaselli, G.F. 2013 AHA/ACC/TOS guideline for the management of overweight and obesity in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and The Obesity Society. Circulation, 2014, 129(25)(Suppl. 2), S102-S138.
[http://dx.doi.org/10.1161/01.cir.0000437739.71477.ee] [PMID: 24222017]
Skov, A.R.; Toubro, S.; Rønn, B.; Holm, L.; Astrup, A. Randomized trial on protein vs carbohydrate in ad libitum fat reduced diet for the treatment of obesity. Int. J. Obes. Relat. Metab. Disord., 1999, 23(5), 528-536.
[http://dx.doi.org/10.1038/sj.ijo.0800867] [PMID: 10375057]
Capel, F.; Viguerie, N.; Vega, N.; Dejean, S.; Arner, P.; Klimcakova, E.; Martinez, J.A.; Saris, W.H.; Holst, C.; Taylor, M.; Oppert, J.M.; Sørensen, T.I.; Clément, K.; Vidal, H.; Langin, D. Contribution of energy restriction and macronutrient composition to changes in adipose tissue gene expression during dietary weight-loss programs in obese women. J. Clin. Endocrinol. Metab., 2008, 93(11), 4315-4322.
[http://dx.doi.org/10.1210/jc.2008-0814] [PMID: 18782868]
Leto, D.; Saltiel, A.R. Regulation of glucose transport by insulin: traffic control of GLUT4. Nat. Rev. Mol. Cell Biol., 2012, 13(6), 383-396.
[http://dx.doi.org/10.1038/nrm3351] [PMID: 22617471]
Herman, M.A.; Kahn, B.B. Glucose transport and sensing in the maintenance of glucose homeostasis and metabolic harmony. J. Clin. Invest., 2006, 116(7), 1767-1775.
[http://dx.doi.org/10.1172/JCI29027] [PMID: 16823474]
Rodríguez, A.; Catalán, V.; Gómez-Ambrosi, J.; Frühbeck, G. Aquaglyceroporins serve as metabolic gateways in adiposity and insulin resistance control. Cell Cycle, 2011, 10(10), 1548-1556.
[http://dx.doi.org/10.4161/cc.10.10.15672] [PMID: 21502813]
Havel, P.J. Dietary fructose: implications for dysregulation of energy homeostasis and lipid/carbohydrate metabolism. Nutr. Rev., 2005, 63(5), 133-157.
[http://dx.doi.org/10.1111/j.1753-4887.2005.tb00132.x] [PMID: 15971409]
Huang, S.; Czech, M.P. The GLUT4 glucose transporter. Cell Metab., 2007, 5(4), 237-252.
[http://dx.doi.org/10.1016/j.cmet.2007.03.006] [PMID: 17403369]
Ceperuelo-Mallafré, V.; Ejarque, M.; Serena, C.; Duran, X.; Montori-Grau, M.; Rodríguez, M.A.; Yanes, O.; Núñez-Roa, C.; Roche, K.; Puthanveetil, P.; Garrido-Sánchez, L.; Saez, E.; Tinahones, F.J.; Garcia-Roves, P.M.; Gómez-Foix, A.M.; Saltiel, A.R.; Vendrell, J.; Fernández-Veledo, S. Adipose tissue glycogen accumulation is associated with obesity-linked inflammation in humans. Mol. Metab., 2015, 5(1), 5-18.
[http://dx.doi.org/10.1016/j.molmet.2015.10.001] [PMID: 26844203]
Frühbeck, G. Protein metabolism. Slow and fast dietary proteins. Nature, 1998, 391(6670), 843-845.
[http://dx.doi.org/dx. DOI: 10.1038/35993] [PMID: 9495333]
Dangin, M.; Boirie, Y.; Guillet, C.; Beaufrère, B. Influence of the protein digestion rate on protein turnover in young and elderly subjects. J. Nutr., 2002, 132(10), 3228S-3233S.
[http://dx.doi.org/10.1093/jn/131.10.3228S] [PMID: 12368423]
Patti, M.E.; Brambilla, E.; Luzi, L.; Landaker, E.J.; Kahn, C.R. Bidirectional modulation of insulin action by amino acids. J. Clin. Invest., 1998, 101(7), 1519-1529.
[http://dx.doi.org/10.1172/JCI1326] [PMID: 9525995]
Pham, P.T.; Heydrick, S.J.; Fox, H.L.; Kimball, S.R.; Jefferson, L.S., Jr; Lynch, C.J. Assessment of cell-signaling pathways in the regulation of mammalian target of rapamycin (mTOR) by amino acids in rat adipocytes. J. Cell. Biochem., 2000, 79(3), 427-441.
[http://dx.doi.org/10.1002/1097-4644(20001201)79:3<427:AID-JCB80>3.0.CO;2-0] [PMID: 10972980]
Gingras, A.C.; Kennedy, S.G.; O’Leary, M.A.; Sonenberg, N.; Hay, N. 4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway. Genes Dev., 1998, 12(4), 502-513.
[http://dx.doi.org/10.1101/gad.12.4.502] [PMID: 9472019]
Lynch, C.J.; Patson, B.J.; Anthony, J.; Vaval, A.; Jefferson, L.S.; Vary, T.C. Leucine is a direct-acting nutrient signal that regulates protein synthesis in adipose tissue. Am. J. Physiol. Endocrinol. Metab., 2002, 283(3), E503-E513.
[http://dx.doi.org/10.1152/ajpendo.00084.2002] [PMID: 12169444]
Catalán, V.; Gómez-Ambrosi, J.; Rodríguez, A.; Ramírez, B.; Andrada, P.; Rotellar, F.; Valentí, V.; Moncada, R.; Martí, P.; Silva, C.; Salvador, J.; Frühbeck, G. Expression of S6K1 in human visceral adipose tissue is upregulated in obesity and related to insulin resistance and inflammation. Acta Diabetol., 2015, 52(2), 257-266.
[http://dx.doi.org/10.1007/s00592-014-0632-9] [PMID: 25118997]
Raught, B.; Gingras, A.C.; Sonenberg, N. The target of rapamycin (TOR) proteins. Proc. Natl. Acad. Sci. USA, 2001, 98(13), 7037-7044.
[http://dx.doi.org/10.1073/pnas.121145898] [PMID: 11416184]
Kraft, C.; Peter, M.; Hofmann, K. Selective autophagy: ubiquitin-mediated recognition and beyond. Nat. Cell Biol., 2010, 12(9), 836-841.
[http://dx.doi.org/10.1038/ncb0910-836] [PMID: 20811356]
Rodríguez, A.; Gómez-Ambrosi, J.; Catalán, V.; Rotellar, F.; Valentí, V.; Silva, C.; Mugueta, C.; Pulido, M.R.; Vázquez, R.; Salvador, J.; Malagón, M.M.; Colina, I.; Frühbeck, G. The ghrelin O-acyltransferase-ghrelin system reduces TNF-α-induced apoptosis and autophagy in human visceral adipocytes. Diabetologia, 2012, 55(11), 3038-3050.
[http://dx.doi.org/10.1007/s00125-012-2671-5] [PMID: 22869322]
Clarke, K.J.; Adams, A.E.; Manzke, L.H.; Pearson, T.W.; Borchers, C.H.; Porter, R.K. A role for ubiquitinylation and the cytosolic proteasome in turnover of mitochondrial uncoupling protein 1 (UCP1). Biochim. Biophys. Acta, 2012, 1817(10), 1759-1767.
[http://dx.doi.org/10.1016/j.bbabio.2012.03.035] [PMID: 22531154]
Pickart, C.M.; Eddins, M.J. Ubiquitin: structures, functions, mechanisms. Biochim. Biophys. Acta, 2004, 1695(1-3), 55-72.
[http://dx.doi.org/10.1016/j.bbamcr.2004.09.019] [PMID: 15571809]
Gross, D.N.; Wan, M.; Birnbaum, M.J. The role of FOXO in the regulation of metabolism. Curr. Diab. Rep., 2009, 9(3), 208-214.
[http://dx.doi.org/10.1007/s11892-009-0034-5] [PMID: 19490822]
Singh, R.; Cuervo, A.M. Autophagy in the cellular energetic balance. Cell Metab., 2011, 13(5), 495-504.
[http://dx.doi.org/10.1016/j.cmet.2011.04.004] [PMID: 21531332]
Rasmussen, B.A.; Breen, D.M.; Lam, T.K. Lipid sensing in the gut, brain and liver. Trends Endocrinol. Metab., 2012, 23(2), 49-55.
[http://dx.doi.org/10.1016/j.tem.2011.11.001] [PMID: 22169756]
Gonzales, A.M.; Orlando, R.A. Role of adipocyte-derived lipoprotein lipase in adipocyte hypertrophy. Nutr. Metab. (Lond.), 2007, 4, 22.
[http://dx.doi.org/10.1186/1743-7075-4-22] [PMID: 17971230]
Ring, A.; Le Lay, S.; Pohl, J.; Verkade, P.; Stremmel, W. Caveolin-1 is required for fatty acid translocase (FAT/CD36) localization and function at the plasma membrane of mouse embryonic fibroblasts. Biochim. Biophys. Acta, 2006, 1761(4), 416-423.
[http://dx.doi.org/10.1016/j.bbalip.2006.03.016] [PMID: 16702023]
Frühbeck, G.; López, M.; Diéguez, C. Role of caveolins in body weight and insulin resistance regulation. Trends Endocrinol. Metab., 2007, 18(5), 177-182.
[http://dx.doi.org/10.1016/j.tem.2007.04.001] [PMID: 17433707]
Catalán, V.; Gómez-Ambrosi, J.; Rodríguez, A.; Silva, C.; Rotellar, F.; Gil, M.J.; Cienfuegos, J.A.; Salvador, J.; Frühbeck, G. Expression of caveolin-1 in human adipose tissue is upregulated in obesity and obesity-associated type 2 diabetes mellitus and related to inflammation. Clin. Endocrinol. (Oxf.), 2008, 68(2), 213-219.
[http://dx.doi.org/dx. DOI: 10.1111/j.1365-2265.2007.03021.x] [PMID: 17803693]
Méndez-Giménez, L.; Rodríguez, A.; Balaguer, I.; Frühbeck, G. Role of aquaglyceroporins and caveolins in energy and metabolic homeostasis. Mol. Cell. Endocrinol., 2014, 397(1-2), 78-92.
[http://dx.doi.org/10.1016/j.mce.2014.06.017] [PMID: 25008241]
Rodríguez, A.; Catalán, V.; Frühbeck, G. Metabolism and satiety. In: Satiation, Satiety and the Control of Food Intake; Blundell, J.; Bellisle, F., Eds.; Woodhead Publishing Series in Food Science, Technology and Nutrition: Spain, 2013; pp. 75-111.
Rodríguez, A.; Catalán, V.; Gómez-Ambrosi, J.; García-Navarro, S.; Rotellar, F.; Valentí, V.; Silva, C.; Gil, M.J.; Salvador, J.; Burrell, M.A.; Calamita, G.; Malagón, M.M.; Frühbeck, G. Insulin- and leptin-mediated control of aquaglyceroporins in human adipocytes and hepatocytes is mediated via the PI3K/Akt/mTOR signaling cascade. J. Clin. Endocrinol. Metab., 2011, 96(4), E586-E597.
[http://dx.doi.org/10.1210/jc.2010-1408] [PMID: 21289260]
Rodríguez, A.; Moreno, N.R.; Balaguer, I.; Méndez-Giménez, L.; Becerril, S.; Catalán, V.; Gómez-Ambrosi, J.; Portincasa, P.; Calamita, G.; Soveral, G.; Malagón, M.M.; Frühbeck, G. Leptin administration restores the altered adipose and hepatic expression of aquaglyceroporins improving the non-alcoholic fatty liver of ob/ob mice. Sci. Rep., 2015, 5, 12067.
[http://dx.doi.org/10.1038/srep12067] [PMID: 26159457]
Maeda, N.; Funahashi, T.; Shimomura, I. Metabolic impact of adipose and hepatic glycerol channels aquaporin 7 and aquaporin 9. Nat. Clin. Pract. Endocrinol. Metab., 2008, 4(11), 627-634.
[http://dx.doi.org/10.1038/ncpendmet0980] [PMID: 18852723]
Schweiger, M.; Schreiber, R.; Haemmerle, G.; Lass, A.; Fledelius, C.; Jacobsen, P.; Tornqvist, H.; Zechner, R.; Zimmermann, R. Adipose triglyceride lipase and hormone-sensitive lipase are the major enzymes in adipose tissue triacylglycerol catabolism. J. Biol. Chem., 2006, 281(52), 40236-40241.
[http://dx.doi.org/10.1074/jbc.M608048200] [PMID: 17074755]
Osuga, J.; Ishibashi, S.; Oka, T.; Yagyu, H.; Tozawa, R.; Fujimoto, A.; Shionoiri, F.; Yahagi, N.; Kraemer, F.B.; Tsutsumi, O.; Yamada, N. Targeted disruption of hormone-sensitive lipase results in male sterility and adipocyte hypertrophy, but not in obesity. Proc. Natl. Acad. Sci. USA, 2000, 97(2), 787-792.
[http://dx.doi.org/10.1073/pnas.97.2.787] [PMID: 10639158]
Frühbeck, G.; Méndez-Giménez, L.; Fernández-Formoso, J.A.; Fernández, S.; Rodríguez, A. Regulation of adipocyte lipolysis. Nutr. Res. Rev., 2014, 27(1), 63-93.
[http://dx.doi.org/10.1017/S095442241400002X] [PMID: 24872083]
Rodríguez, A.; Gómez-Ambrosi, J.; Catalán, V.; Ezquerro, S.; Méndez-Giménez, L.; Becerril, S.; Ibáñez, P.; Vila, N.; Margall, M.A.; Moncada, R.; Valentí, V.; Silva, C.; Salvador, J.; Frühbeck, G. Guanylin and uroguanylin stimulate lipolysis in human visceral adipocytes. Int. J. Obes., 2016, 40(9), 1405-1415.
[http://dx.doi.org/10.1038/ijo.2016.66] [PMID: 27108812]
Arner, P. Differences in lipolysis between human subcutaneous and omental adipose tissues. Ann. Med., 1995, 27(4), 435-438.
[http://dx.doi.org/10.3109/07853899709002451] [PMID: 8519504]
Frühbeck, G.; Gómez-Ambrosi, J.; Salvador, J. Leptin-induced lipolysis opposes the tonic inhibition of endogenous adenosine in white adipocytes. FASEB J., 2001, 15(2), 333-340.
[http://dx.doi.org/10.1096/fj.00-0249com] [PMID: 11156949]
Frühbeck, G. Obesity: aquaporin enters the picture. Nature, 2005, 438(7067), 436-437.
[http://dx.doi.org/10.1038/438436b] [PMID: 16306977]
Rodríguez, A.; Catalán, V.; Gómez-Ambrosi, J.; Frühbeck, G. Role of aquaporin-7 in the pathophysiological control of fat accumulation in mice. FEBS Lett., 2006, 580(20), 4771-4776.
[http://dx.doi.org/10.1016/j.febslet.2006.07.080] [PMID: 16919625]
Kazumi, T.; Vranic, M.; Steiner, G. Triglyceride kinetics: effects of dietary glucose, sucrose, or fructose alone or with hyperinsulinemia. Am. J. Physiol., 1986, 250(3 Pt 1), E325-E330.
[PMID: 3513615]
Björkman, O.; Gunnarsson, R.; Hagström, E.; Felig, P.; Wahren, J. Splanchnic and renal exchange of infused fructose in insulin-deficient type 1 diabetic patients and healthy controls. J. Clin. Invest., 1989, 83(1), 52-59.
[http://dx.doi.org/10.1172/JCI113884] [PMID: 2910919]
Bode, C.; Dürr, H.K.; Bode, J.C. Effect of fructose feeding on the activity of enzymes of glycolysis, gluconeogenesis, and the pentose phosphate shunt in the liver and jejunal mucosa of rats. Horm. Metab. Res., 1981, 13(7), 379-383.
[http://dx.doi.org/10.1055/s-2007-1019275] [PMID: 7274991]
Rizkalla, S.W. Health implications of fructose consumption: A review of recent data. Nutr. Metab. (Lond.), 2010, 7, 82.
[http://dx.doi.org/10.1186/1743-7075-7-82] [PMID: 21050460]
Taleb-Dida, N.; Krouf, D.; Bouchenak, M. Globularia alypum aqueous extract decreases hypertriglyceridemia and ameliorates oxidative status of the muscle, kidney, and heart in rats fed a high-fructose diet. Nutr. Res., 2011, 31(6), 488-495.
[http://dx.doi.org/10.1016/j.nutres.2011.05.005] [PMID: 21745631]
Saha, A.K.; Ruderman, N.B. Malonyl-CoA and AMP-activated protein kinase: an expanding partnership. Mol. Cell. Biochem., 2003, 253(1-2), 65-70.
[http://dx.doi.org/10.1023/A:1026053302036] [PMID: 14619957]
Long, Y.C.; Zierath, J.R. AMP-activated protein kinase signaling in metabolic regulation. J. Clin. Invest., 2006, 116(7), 1776-1783.
[http://dx.doi.org/10.1172/JCI29044] [PMID: 16823475]
Rodríguez, A.; Catalán, V.; Becerril, S.; Gil, M.J.; Mugueta, C.; Gómez-Ambrosi, J.; Frühbeck, G. Impaired adiponectin-AMPK signalling in insulin-sensitive tissues of hypertensive rats. Life Sci., 2008, 83(15-16), 540-549.
[http://dx.doi.org/10.1016/j.lfs.2008.07.022] [PMID: 18761357]
Ruderman, N.; Flier, J.S. Cell biology. Chewing the fat--ACC and energy balance. Science, 2001, 291(5513), 2558-2559.
[http://dx.doi.org/10.1126/science.1060277] [PMID: 11286278]
Brownsey, R.W.; Boone, A.N.; Elliott, J.E.; Kulpa, J.E.; Lee, W.M. Regulation of acetyl-CoA carboxylase. Biochem. Soc. Trans., 2006, 34(Pt 2), 223-227.
[http://dx.doi.org/10.1042/BST0340223] [PMID: 16545081]
Johansson, K.; Neovius, M.; Hemmingsson, E. Effects of anti-obesity drugs, diet, and exercise on weight-loss maintenance after a very-low-calorie diet or low-calorie diet: a systematic review and meta-analysis of randomized controlled trials. Am. J. Clin. Nutr., 2014, 99(1), 14-23.
[http://dx.doi.org/10.3945/ajcn.113.070052] [PMID: 24172297]
Vink, R.G.; Roumans, N.J.; Arkenbosch, L.A.; Mariman, E.C.; van Baak, M.A. The effect of rate of weight loss on long-term weight regain in adults with overweight and obesity. Obesity (Silver Spring), 2016, 24(2), 321-327.
[http://dx.doi.org/10.1002/oby.21346] [PMID: 26813524]
Parretti, H.M.; Jebb, S.A.; Johns, D.J.; Lewis, A.L.; Christian-Brown, A.M.; Aveyard, P. Clinical effectiveness of very-low-energy diets in the management of weight loss: a systematic review and meta-analysis of randomized controlled trials. Obes. Rev., 2016, 17(3), 225-234.
[http://dx.doi.org/10.1111/obr.12366] [PMID: 26775902]
Colles, S.L.; Dixon, J.B.; Marks, P.; Strauss, B.J.; O’Brien, P.E. Preoperative weight loss with a very-low-energy diet: quantitation of changes in liver and abdominal fat by serial imaging. Am. J. Clin. Nutr., 2006, 84(2), 304-311.
[http://dx.doi.org/10.1093/ajcn/84.2.304] [PMID: 16895876]
Kiddy, D.S.; Hamilton-Fairley, D.; Bush, A.; Short, F.; Anyaoku, V.; Reed, M.J.; Franks, S. Improvement in endocrine and ovarian function during dietary treatment of obese women with polycystic ovary syndrome. Clin. Endocrinol. (Oxf.), 1992, 36(1), 105-111.
[http://dx.doi.org/10.1111/j.1365-2265.1992.tb02909.x] [PMID: 1559293]
Tsagareli, V.; Noakes, M.; Norman, R.J. Effect of a very-low-calorie diet on in vitro fertilization outcomes. Fertil. Steril., 2006, 86(1), 227-229.
[http://dx.doi.org/10.1016/j.fertnstert.2005.12.041] [PMID: 16750829]
Norman, R.J.; Noakes, M.; Wu, R.; Davies, M.J.; Moran, L.; Wang, J.X. Improving reproductive performance in overweight/obese women with effective weight management. Hum. Reprod. Update, 2004, 10(3), 267-280.
[http://dx.doi.org/10.1093/humupd/dmh018] [PMID: 15140873]
Moran, L.J.; Noakes, M.; Clifton, P.M.; Tomlinson, L.; Galletly, C.; Norman, R.J. Dietary composition in restoring reproductive and metabolic physiology in overweight women with polycystic ovary syndrome. J. Clin. Endocrinol. Metab., 2003, 88(2), 812-819.
[http://dx.doi.org/10.1210/jc.2002-020815] [PMID: 12574218]
Chaston, T.B.; Dixon, J.B. Factors associated with percent change in visceral versus subcutaneous abdominal fat during weight loss: findings from a systematic review. Int. J. Obes., 2008, 32(4), 619-628.
[http://dx.doi.org/10.1038/sj.ijo.0803761] [PMID: 18180786]
Bucci, M.; Karmi, A.C.; Iozzo, P.; Fielding, B.A.; Viljanen, A.; Badeau, R.M.; Borra, R.; Saunavaara, V.; Pham, T.; Hannukainen, J.C.; Kalliokoski, K.; Haaparanta-Solin, M.; Viljanen, T.; Parkkola, R.; Frayn, K.N.; Nuutila, P. Enhanced fatty acid uptake in visceral adipose tissue is not reversed by weight loss in obese individuals with the metabolic syndrome. Diabetologia, 2015, 58(1), 158-164.
[http://dx.doi.org/10.1007/s00125-014-3402-x] [PMID: 25331375]
La Vecchia, C.; Negri, E.; D’Avanzo, B.; Franceschi, S.; Boyle, P. Risk factors for gallstone disease requiring surgery. Int. J. Epidemiol., 1991, 20(1), 209-215.
[http://dx.doi.org/10.1093/ije/20.1.209] [PMID: 2066222]
Broomfield, P.H.; Chopra, R.; Sheinbaum, R.C.; Bonorris, G.G.; Silverman, A.; Schoenfield, L.J.; Marks, J.W. Effects of ursodeoxycholic acid and aspirin on the formation of lithogenic bile and gallstones during loss of weight. N. Engl. J. Med., 1988, 319(24), 1567-1572.
[http://dx.doi.org/10.1056/NEJM198812153192403] [PMID: 3200265]
Yang, H.; Petersen, G.M.; Roth, M.P.; Schoenfield, L.J.; Marks, J.W. Risk factors for gallstone formation during rapid loss of weight. Dig. Dis. Sci., 1992, 37(6), 912-918.
[http://dx.doi.org/10.1007/BF01300390] [PMID: 1587196]
Williams, C.; Gowan, R.; Perey, B.J. A double-blind placebo-controlled trial of ursodeoxycholic acid in the prevention of gallstones during weight loss after vertical banded gastroplasty. Obes. Surg., 1993, 3(3), 257-259.
[http://dx.doi.org/10.1381/096089293765559278] [PMID: 10757929]
Worobetz, L.J.; Inglis, F.G.; Shaffer, E.A. The effect of ursodeoxycholic acid therapy on gallstone formation in the morbidly obese during rapid weight loss. Am. J. Gastroenterol., 1993, 88(10), 1705-1710.
[PMID: 8213711]
Sugerman, H.J.; Brewer, W.H.; Shiffman, M.L.; Brolin, R.E.; Fobi, M.A.; Linner, J.H.; MacDonald, K.G.; MacGregor, A.M.; Martin, L.F.; Oram-Smith, J.C. A multicenter, placebo-controlled, randomized, double-blind, prospective trial of prophylactic ursodiol for the prevention of gallstone formation following gastric-bypass-induced rapid weight loss. Am. J. Surg., 1995, 169(1), 91-96.
[http://dx.doi.org/10.1016/S0002-9610(99)80115-9] [PMID: 7818005]
Wudel, L.J., Jr; Wright, J.K.; Debelak, J.P.; Allos, T.M.; Shyr, Y.; Chapman, W.C. Prevention of gallstone formation in morbidly obese patients undergoing rapid weight loss: results of a randomized controlled pilot study. J. Surg. Res., 2002, 102(1), 50-56.
[http://dx.doi.org/10.1006/jsre.2001.6322] [PMID: 11792152]
Miller, K.; Hell, E.; Lang, B.; Lengauer, E. Gallstone formation prophylaxis after gastric restrictive procedures for weight loss: a randomized double-blind placebo-controlled trial. Ann. Surg., 2003, 238(5), 697-702.
[http://dx.doi.org/10.1097/01.sla.0000094305.77843.cf] [PMID: 14578732]
Schauer, P.R.; Burguera, B.; Ikramuddin, S.; Cottam, D.; Gourash, W.; Hamad, G.; Eid, G.M.; Mattar, S.; Ramanathan, R.; Barinas-Mitchel, E.; Rao, R.H.; Kuller, L.; Kelley, D. Effect of laparoscopic Roux-en Y gastric bypass on type 2 diabetes mellitus. Ann. Surg., 2003, 238(4), 467-484.
[PMID: 14530719]
Portincasa, P.; Moschetta, A.; Palasciano, G. Cholesterol gallstone disease. Lancet, 2006, 368(9531), 230-239.
[http://dx.doi.org/10.1016/S0140-6736(06)69044-2] [PMID: 16844493]
Portincasa, P.; Di Ciaula, A.; Wang, H.H.; Palasciano, G.; van Erpecum, K.J.; Moschetta, A.; Wang, D.Q. Coordinate regulation of gallbladder motor function in the gut-liver axis. Hepatology, 2008, 47(6), 2112-2126.
[http://dx.doi.org/10.1002/hep.22204] [PMID: 18506897]
Portincasa, P.; Wang, D.Q. Intestinal absorption, hepatic synthesis, and biliary secretion of cholesterol: where are we for cholesterol gallstone formation? Hepatology, 2012, 55(5), 1313-1316.
[http://dx.doi.org/10.1002/hep.25604] [PMID: 22271308]
Lammert, F.; Gurusamy, K.; Ko, C.W.; Miquel, J.F.; Méndez-Sánchez, N.; Portincasa, P.; van Erpecum, K.J.; van Laarhoven, C.J.; Wang, D.Q. Gallstones. Nat. Rev. Dis. Primers, 2016, 2, 16024.
[http://dx.doi.org/10.1038/nrdp.2016.24] [PMID: 27121416]
Bonfrate, L.; Wang, D.Q.; Garruti, G.; Portincasa, P. Obesity and the risk and prognosis of gallstone disease and pancreatitis. Best Pract. Res. Clin. Gastroenterol., 2014, 28(4), 623-635.
[http://dx.doi.org/10.1016/j.bpg.2014.07.013] [PMID: 25194180]
Johansson, K.; Sundström, J.; Marcus, C.; Hemmingsson, E.; Neovius, M. Risk of symptomatic gallstones and cholecystectomy after a very-low-calorie diet or low-calorie diet in a commercial weight loss program: 1-year matched cohort study. Int. J. Obes., 2014, 38(2), 279-284.
[http://dx.doi.org/10.1038/ijo.2013.83] [PMID: 23736359]
Festi, D.; Colecchia, A.; Orsini, M.; Sangermano, A.; Sottili, S.; Simoni, P.; Mazzella, G.; Villanova, N.; Bazzoli, F.; Lapenna, D.; Petroni, M.L.; Pavesi, S.; Neri, M.; Roda, E. Gallbladder motility and gallstone formation in obese patients following very low calorie diets. Use it (fat) to lose it (well). Int. J. Obes. Relat. Metab. Disord., 1998, 22(6), 592-600.
[http://dx.doi.org/10.1038/sj.ijo.0800634] [PMID: 9665682]
Gebhard, R.L.; Prigge, W.F.; Ansel, H.J.; Schlasner, L.; Ketover, S.R.; Sande, D.; Holtmeier, K.; Peterson, F.J. The role of gallbladder emptying in gallstone formation during diet-induced rapid weight loss. Hepatology, 1996, 24(3), 544-548.
[http://dx.doi.org/10.1002/hep.510240313] [PMID: 8781321]
Weinsier, R.L.; Wilson, L.J.; Lee, J. Medically safe rate of weight loss for the treatment of obesity: a guideline based on risk of gallstone formation. Am. J. Med., 1995, 98(2), 115-117.
[http://dx.doi.org/10.1016/S0002-9343(99)80394-5] [PMID: 7847427]
Heshka, S.; Spitz, A.; Nuñez, C.; Fittante, A.M.; Heymsfield, S.B.; Pi-Sunyer, F.X. Obesity and risk of gallstone development on a 1200 kcal/d (5025 Kj/d) regular food diet. Int. J. Obes. Relat. Metab. Disord., 1996, 20(5), 450-454.
[PMID: 8696424]
Al-Jiffry, B.O.; Shaffer, E.A.; Saccone, G.T.; Downey, P.; Kow, L.; Toouli, J. Changes in gallbladder motility and gallstone formation following laparoscopic gastric banding for morbid obestity. Can. J. Gastroenterol., 2003, 17(3), 169-174.
[http://dx.doi.org/10.1155/2003/392719] [PMID: 12677265]
Report of the joint WHO/FAO expert consultation. Diet, nutrition and the prevention of chronic diseases. World Health Organ. Tech. Rep. Ser., 2003, 916, i-viii, 1-149.backcover..
[PMID: 12768890]
Garg, A.; Grundy, S.M.; Unger, R.H. Comparison of effects of high and low carbohydrate diets on plasma lipoproteins and insulin sensitivity in patients with mild NIDDM. Diabetes, 1992, 41(10), 1278-1285.
[http://dx.doi.org/10.2337/diab.41.10.1278] [PMID: 1397701]
Shai, I.; Schwarzfuchs, D.; Henkin, Y.; Shahar, D.R.; Witkow, S.; Greenberg, I.; Golan, R.; Fraser, D.; Bolotin, A.; Vardi, H.; Tangi-Rozental, O.; Zuk-Ramot, R.; Sarusi, B.; Brickner, D.; Schwartz, Z.; Sheiner, E.; Marko, R.; Katorza, E.; Thiery, J.; Fiedler, G.M.; Blüher, M.; Stumvoll, M.; Stampfer, M.J. Weight loss with a low-carbohydrate, Mediterranean, or low-fat diet. N. Engl. J. Med., 2008, 359(3), 229-241.
[http://dx.doi.org/10.1056/NEJMoa0708681] [PMID: 18635428]
Tay, J.; Luscombe-Marsh, N.D.; Thompson, C.H.; Noakes, M.; Buckley, J.D.; Wittert, G.A.; Yancy, W.S., Jr; Brinkworth, G.D. Comparison of low- and high-carbohydrate diets for type 2 diabetes management: a randomized trial. Am. J. Clin. Nutr., 2015, 102(4), 780-790.
[http://dx.doi.org/10.3945/ajcn.115.112581] [PMID: 26224300]
Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA, 2001, 285(19), 2486-2497.
[http://dx.doi.org/10.1001/jama.285.19.2486] [PMID: 11368702]
Vidon, C.; Boucher, P.; Cachefo, A.; Peroni, O.; Diraison, F.; Beylot, M. Effects of isoenergetic high-carbohydrate compared with high-fat diets on human cholesterol synthesis and expression of key regulatory genes of cholesterol metabolism. Am. J. Clin. Nutr., 2001, 73(5), 878-884.
[http://dx.doi.org/10.1093/ajcn/73.5.878] [PMID: 11333840]
Nordmann, A.J.; Nordmann, A.; Briel, M.; Keller, U.; Yancy, W.S., Jr; Brehm, B.J.; Bucher, H.C. Effects of low-carbohydrate vs low-fat diets on weight loss and cardiovascular risk factors: a meta-analysis of randomized controlled trials. Arch. Intern. Med., 2006, 166(3), 285-293.
[http://dx.doi.org/10.1001/archinte.166.3.285] [PMID: 16476868]
Bueno, N.B.; de Melo, I.S.; de Oliveira, S.L.; da Rocha Ataide, T. Very-low-carbohydrate ketogenic diet v. low-fat diet for long-term weight loss: a meta-analysis of randomised controlled trials. Br. J. Nutr., 2013, 110(7), 1178-1187.
[http://dx.doi.org/10.1017/S0007114513000548] [PMID: 23651522]
Golay, A.; Allaz, A.F.; Morel, Y.; de Tonnac, N.; Tankova, S.; Reaven, G. Similar weight loss with low- or high-carbohydrate diets. Am. J. Clin. Nutr., 1996, 63(2), 174-178.
[http://dx.doi.org/10.1093/ajcn/63.2.174] [PMID: 8561057]
Samaha, F.F.; Iqbal, N.; Seshadri, P.; Chicano, K.L.; Daily, D.A.; McGrory, J.; Williams, T.; Williams, M.; Gracely, E.J.; Stern, L. A low-carbohydrate as compared with a low-fat diet in severe obesity. N. Engl. J. Med., 2003, 348(21), 2074-2081.
[http://dx.doi.org/10.1056/NEJMoa022637] [PMID: 12761364]
Samaha, F.F.; Foster, G.D.; Makris, A.P. Low-carbohydrate diets, obesity, and metabolic risk factors for cardiovascular disease. Curr. Atheroscler. Rep., 2007, 9(6), 441-447.
[http://dx.doi.org/10.1007/s11883-007-0059-7] [PMID: 18377783]
Noakes, M.; Keogh, J.B.; Foster, P.R.; Clifton, P.M. Effect of an energy-restricted, high-protein, low-fat diet relative to a conventional high-carbohydrate, low-fat diet on weight loss, body composition, nutritional status, and markers of cardiovascular health in obese women. Am. J. Clin. Nutr., 2005, 81(6), 1298-1306.
[http://dx.doi.org/10.1093/ajcn/81.6.1298] [PMID: 15941879]
Poppitt, S.D.; Keogh, G.F.; Prentice, A.M.; Williams, D.E.; Sonnemans, H.M.; Valk, E.E.; Robinson, E.; Wareham, N.J. Long-term effects of ad libitum low-fat, high-carbohydrate diets on body weight and serum lipids in overweight subjects with metabolic syndrome. Am. J. Clin. Nutr., 2002, 75(1), 11-20.
[http://dx.doi.org/10.1093/ajcn/75.1.11] [PMID: 11756055]
Toubro, S.; Astrup, A. Randomised comparison of diets for maintaining obese subjects’ weight after major weight loss: ad lib, low fat, high carbohydrate diet v fixed energy intake. BMJ, 1997, 314(7073), 29-34.
[http://dx.doi.org/10.1136/bmj.314.7073.29] [PMID: 9001476]
A critique of low-carbohydrate ketogenic weight reduction regimens. A review of Dr. Atkins’ diet revolution. JAMA, 1973, 224(10), 1415-1419.
[http://dx.doi.org/10.1001/jama.1973.03220240055018] [PMID: 4739993]
Abete, I.; Astrup, A.; Martínez, J.A.; Thorsdottir, I.; Zulet, M.A. Obesity and the metabolic syndrome: role of different dietary macronutrient distribution patterns and specific nutritional components on weight loss and maintenance. Nutr. Rev., 2010, 68(4), 214-231.
[http://dx.doi.org/10.1111/j.1753-4887.2010.00280.x] [PMID: 20416018]
Westerterp-Plantenga, M.S. How are normal, high- or low-protein diets defined? Br. J. Nutr., 2007, 97(2), 217-218.
[http://dx.doi.org/10.1017/S0007114507381348] [PMID: 17298688]
Campbell, B.; Kreider, R.B.; Ziegenfuss, T.; La Bounty, P.; Roberts, M.; Burke, D.; Landis, J.; Lopez, H.; Antonio, J. International Society of Sports Nutrition position stand: protein and exercise. J. Int. Soc. Sports Nutr., 2007, 4, 8.
[http://dx.doi.org/10.1186/1550-2783-4-8] [PMID: 17908291]
Paddon-Jones, D.; Leidy, H. Dietary protein and muscle in older persons. Curr. Opin. Clin. Nutr. Metab. Care, 2014, 17(1), 5-11.
[http://dx.doi.org/10.1097/MCO.0000000000000011] [PMID: 24310053]
Fulgoni, V.L. III Current protein intake in America: analysis of the National Health and Nutrition Examination Survey, 2003-2004. Am. J. Clin. Nutr., 2008, 87(5), 1554S-1557S.
[http://dx.doi.org/10.1093/ajcn/87.5.1554S] [PMID: 18469286]
Lemon, P.W. Do athletes need more dietary protein and amino acids? Int. J. Sport Nutr., 1995, 5(Suppl.), S39-S61.
[http://dx.doi.org/10.1123/ijsn.5.s1.s39] [PMID: 7550257]
Antonio, J.; Peacock, C.A.; Ellerbroek, A.; Fromhoff, B.; Silver, T. The effects of consuming a high protein diet (4.4 g/kg/d) on body composition in resistance-trained individuals. J. Int. Soc. Sports Nutr., 2014, 11, 19.
[http://dx.doi.org/10.1186/1550-2783-11-19] [PMID: 24834017]
Rand, W.M.; Pellett, P.L.; Young, V.R. Meta-analysis of nitrogen balance studies for estimating protein requirements in healthy adults. Am. J. Clin. Nutr., 2003, 77(1), 109-127.
[http://dx.doi.org/10.1093/ajcn/77.1.109] [PMID: 12499330]
Schmidt, J.A.; Rinaldi, S.; Scalbert, A.; Ferrari, P.; Achaintre, D.; Gunter, M.J.; Appleby, P.N.; Key, T.J.; Travis, R.C. Plasma concentrations and intakes of amino acids in male meat-eaters, fish-eaters, vegetarians and vegans: a cross-sectional analysis in the EPIC-Oxford cohort. Eur. J. Clin. Nutr., 2016, 70(3), 306-312.
[http://dx.doi.org/10.1038/ejcn.2015.144] [PMID: 26395436]
Tipton, K.D. Efficacy and consequences of very-high-protein diets for athletes and exercisers. Proc. Nutr. Soc., 2011, 70(2), 205-214.
[http://dx.doi.org/10.1017/S0029665111000024] [PMID: 21375795]
Krieger, J.W.; Sitren, H.S.; Daniels, M.J.; Langkamp-Henken, B. Effects of variation in protein and carbohydrate intake on body mass and composition during energy restriction: a meta-regression 1. Am. J. Clin. Nutr., 2006, 83(2), 260-274.
[http://dx.doi.org/10.1093/ajcn/83.2.260] [PMID: 16469983]
Ravussin, E.; Lillioja, S.; Anderson, T.E.; Christin, L.; Bogardus, C. Determinants of 24-hour energy expenditure in man. Methods and results using a respiratory chamber. J. Clin. Invest., 1986, 78(6), 1568-1578.
[http://dx.doi.org/10.1172/JCI112749] [PMID: 3782471]
Wolfe, R.R. The underappreciated role of muscle in health and disease. Am. J. Clin. Nutr., 2006, 84(3), 475-482.
[http://dx.doi.org/10.1093/ajcn/84.3.475] [PMID: 16960159]
Clifton, P.M.; Keogh, J. Metabolic effects of high-protein diets. Curr. Atheroscler. Rep., 2007, 9(6), 472-478.
[http://dx.doi.org/10.1007/s11883-007-0063-y] [PMID: 18377787]
Leidy, H.J.; Carnell, N.S.; Mattes, R.D.; Campbell, W.W. Higher protein intake preserves lean mass and satiety with weight loss in pre-obese and obese women. Obesity (Silver Spring), 2007, 15(2), 421-429.
[http://dx.doi.org/10.1038/oby.2007.531] [PMID: 17299116]
Whitehead, J.M.; McNeill, G.; Smith, J.S. The effect of protein intake on 24-h energy expenditure during energy restriction. Int. J. Obes. Relat. Metab. Disord., 1996, 20(8), 727-732.
[PMID: 8856395]
Brehm, B.J.; D’Alessio, D.A. Benefits of high-protein weight loss diets: enough evidence for practice? Curr. Opin. Endocrinol. Diabetes Obes., 2008, 15(5), 416-421.
[http://dx.doi.org/10.1097/MED.0b013e328308dc13] [PMID: 18769212]
Phillips, S.M. Dietary protein for athletes: from requirements to metabolic advantage. Appl. Physiol. Nutr. Metab., 2006, 31(6), 647-654.
[http://dx.doi.org/10.1139/h06-035] [PMID: 17213878]
Roig, M.; O’Brien, K.; Kirk, G.; Murray, R.; McKinnon, P.; Shadgan, B.; Reid, W.D. The effects of eccentric versus concentric resistance training on muscle strength and mass in healthy adults: a systematic review with meta-analysis. Br. J. Sports Med., 2009, 43(8), 556-568.
[http://dx.doi.org/10.1136/bjsm.2008.051417] [PMID: 18981046]
Meckling, K.A.; Sherfey, R. A randomized trial of a hypocaloric high-protein diet, with and without exercise, on weight loss, fitness, and markers of the Metabolic Syndrome in overweight and obese women. Appl. Physiol. Nutr. Metab., 2007, 32(4), 743-752.
[http://dx.doi.org/10.1139/H07-059] [PMID: 17622289]
Soenen, S.; Westerterp-Plantenga, M.S. Proteins and satiety: implications for weight management. Curr. Opin. Clin. Nutr. Metab. Care, 2008, 11(6), 747-751.
[http://dx.doi.org/10.1097/MCO.0b013e328311a8c4] [PMID: 18827579]
Weigle, D.S.; Breen, P.A.; Matthys, C.C.; Callahan, H.S.; Meeuws, K.E.; Burden, V.R.; Purnell, J.Q. A high-protein diet induces sustained reductions in appetite, ad libitum caloric intake, and body weight despite compensatory changes in diurnal plasma leptin and ghrelin concentrations. Am. J. Clin. Nutr., 2005, 82(1), 41-48.
[http://dx.doi.org/10.1093/ajcn/82.1.41] [PMID: 16002798]
Lejeune, M.P.; Westerterp, K.R.; Adam, T.C.; Luscombe-Marsh, N.D.; Westerterp-Plantenga, M.S. Ghrelin and glucagon-like peptide 1 concentrations, 24-h satiety, and energy and substrate metabolism during a high-protein diet and measured in a respiration chamber. Am. J. Clin. Nutr., 2006, 83(1), 89-94.
[http://dx.doi.org/10.1093/ajcn/83.1.89] [PMID: 16400055]
Tessari, P.; Kiwanuka, E.; Zanetti, M.; Barazzoni, R. Postprandial body protein synthesis and amino acid catabolism measured with leucine and phenylalanine-tyrosine tracers. Am. J. Physiol. Endocrinol. Metab., 2003, 284(5), E1037-E1042.
[http://dx.doi.org/10.1152/ajpendo.00416.2002] [PMID: 12676651]
Pannemans, D.L.; Wagenmakers, A.J.; Westerterp, K.R.; Schaafsma, G.; Halliday, D. Effect of protein source and quantity on protein metabolism in elderly women. Am. J. Clin. Nutr., 1998, 68(6), 1228-1235.
[http://dx.doi.org/10.1093/ajcn/68.6.1228] [PMID: 9846851]
Mikkelsen, P.B.; Toubro, S.; Astrup, A. Effect of fat-reduced diets on 24-h energy expenditure: comparisons between animal protein, vegetable protein, and carbohydrate. Am. J. Clin. Nutr., 2000, 72(5), 1135-1141.
[http://dx.doi.org/10.1093/ajcn/72.5.1135] [PMID: 11063440]
Tappy, L. Thermic effect of food and sympathetic nervous system activity in humans. Reprod. Nutr. Dev., 1996, 36(4), 391-397.
[http://dx.doi.org/10.1051/rnd:19960405] [PMID: 8878356]
Leidy, H.J.; Clifton, P.M.; Astrup, A.; Wycherley, T.P.; Westerterp-Plantenga, M.S.; Luscombe-Marsh, N.D.; Woods, S.C.; Mattes, R.D. The role of protein in weight loss and maintenance. Am. J. Clin. Nutr., 2015, 101(6), 1320S-1329S.
[http://dx.doi.org/10.3945/ajcn.114.084038] [PMID: 25926512]
Wycherley, T.P.; Buckley, J.D.; Noakes, M.; Clifton, P.M.; Brinkworth, G.D. Comparison of the effects of weight loss from a high-protein versus standard-protein energy-restricted diet on strength and aerobic capacity in overweight and obese men. Eur. J. Nutr., 2013, 52(1), 317-325.
[http://dx.doi.org/10.1007/s00394-012-0338-0] [PMID: 22406907]
Santesso, N.; Akl, E.A.; Bianchi, M.; Mente, A.; Mustafa, R.; Heels-Ansdell, D.; Schünemann, H.J. Effects of higher- versus lower-protein diets on health outcomes: a systematic review and meta-analysis. Eur. J. Clin. Nutr., 2012, 66(7), 780-788.
[http://dx.doi.org/10.1038/ejcn.2012.37] [PMID: 22510792]
Della-Pace, I.D.; Rambo, L.M.; Ribeiro, L.R.; Saraiva, A.L.; de Oliveira, S.M.; Silva, C.R.; Villarinho, J.G.; Rossato, M.F.; Ferreira, J.; de Carvalho, L.M.; de Oliveira Lima, F.; Furian, A.F.; Oliveria, M.S.; Santos, A.R.; Facundo, V.A.; Fighera, M.R.; Royes, L.F. Triterpene 3β, 6β, 16β trihidroxilup-20(29)-ene protects against excitability and oxidative damage induced by pentylenetetrazol: the role of Na(+),K(+)-ATPase activity. Neuropharmacology, 2013, 67, 455-464.
[http://dx.doi.org/10.1016/j.neuropharm.2012.10.022] [PMID: 23219656]
Rietman, A.; Schwarz, J.; Tomé, D.; Kok, F.J.; Mensink, M. High dietary protein intake, reducing or eliciting insulin resistance? Eur. J. Clin. Nutr., 2014, 68(9), 973-979.
[http://dx.doi.org/10.1038/ejcn.2014.123] [PMID: 24986822]
Chaumontet, C.; Even, P.C.; Schwarz, J.; Simonin-Foucault, A.; Piedcoq, J.; Fromentin, G.; Azzout-Marniche, D.; Tomé, D. High dietary protein decreases fat deposition induced by high-fat and high-sucrose diet in rats. Br. J. Nutr., 2015, 114(8), 1132-1142.
[http://dx.doi.org/10.1017/S000711451500238X] [PMID: 26285832]
Blouet, C.; Mariotti, F.; Azzout-Marniche, D.; Bos, C.; Mathé, V.; Tomé, D.; Huneau, J.F. The reduced energy intake of rats fed a high-protein low-carbohydrate diet explains the lower fat deposition, but macronutrient substitution accounts for the improved glycemic control. J. Nutr., 2006, 136(7), 1849-1854.
[http://dx.doi.org/10.1093/jn/136.7.1849] [PMID: 16772448]
Stepien, M.; Gaudichon, C.; Fromentin, G.; Even, P.; Tomé, D.; Azzout-Marniche, D. Increasing protein at the expense of carbohydrate in the diet down-regulates glucose utilization as glucose sparing effect in rats. PLoS One, 2011, 6(2)e14664
[http://dx.doi.org/10.1371/journal.pone.0014664] [PMID: 21326875]
Clifton, P.M.; Keogh, J.B.; Noakes, M. Long-term effects of a high-protein weight-loss diet. Am. J. Clin. Nutr., 2008, 87(1), 23-29.
[http://dx.doi.org/10.1093/ajcn/87.1.23] [PMID: 18175733]
Friedman, A.N. High-protein diets: potential effects on the kidney in renal health and disease. Am. J. Kidney Dis., 2004, 44(6), 950-962.
[http://dx.doi.org/10.1053/j.ajkd.2004.08.020] [PMID: 15558517]
Levine, M.E.; Suarez, J.A.; Brandhorst, S.; Balasubramanian, P.; Cheng, C.W.; Madia, F.; Fontana, L.; Mirisola, M.G.; Guevara-Aguirre, J.; Wan, J.; Passarino, G.; Kennedy, B.K.; Wei, M.; Cohen, P.; Crimmins, E.M.; Longo, V.D. Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population. Cell Metab., 2014, 19(3), 407-417.
[http://dx.doi.org/10.1016/j.cmet.2014.02.006] [PMID: 24606898]
Linos, E.; Willett, W.C. Diet and breast cancer risk reduction. J. Natl. Compr. Canc. Netw., 2007, 5(8), 711-718.
[http://dx.doi.org/10.6004/jnccn.2007.0072] [PMID: 17927928]
Michaud, D.S.; Augustsson, K.; Rimm, E.B.; Stampfer, M.J.; Willet, W.C.; Giovannucci, E. A prospective study on intake of animal products and risk of prostate cancer. Cancer Causes Control, 2001, 12(6), 557-567.
[http://dx.doi.org/10.1023/A:1011256201044] [PMID: 11519764]
Metges, C.C.; Barth, C.A. Metabolic consequences of a high dietary-protein intake in adulthood: assessment of the available evidence. J. Nutr., 2000, 130(4), 886-889.
[http://dx.doi.org/10.1093/jn/130.4.886] [PMID: 10736347]
Martin, W.F.; Armstrong, L.E.; Rodríguez, N.R. Dietary protein intake and renal function. Nutr. Metab. (Lond.), 2005, 2, 25.
[http://dx.doi.org/10.1186/1743-7075-2-25] [PMID: 16174292]
Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults--The Evidence Report. National Institutes of Health. Obes. Res., 1998, 6(Suppl. 2), 51S-209S.
[PMID: 9813653]
Tobias, D.K.; Chen, M.; Manson, J.E.; Ludwig, D.S.; Willett, W.; Hu, F.B. Effect of low-fat diet interventions versus other diet interventions on long-term weight change in adults: a systematic review and meta-analysis. Lancet Diabetes Endocrinol., 2015, 3(12), 968-979.
[http://dx.doi.org/10.1016/S2213-8587(15)00367-8] [PMID: 26527511]
Pirozzo, S.; Summerbell, C.; Cameron, C.; Glasziou, P. Should we recommend low-fat diets for obesity? Obes. Rev., 2003, 4(2), 83-90.
[http://dx.doi.org/10.1046/j.1467-789X.2003.00099.x] [PMID: 12760443]
Westerterp-Plantenga, M.S. Fat intake and energy-balance effects. Physiol. Behav., 2004, 83(4), 579-585.
[http://dx.doi.org/10.1016/j.physbeh.2004.07.027] [PMID: 15621063]
Katan, M.B.; Grundy, S.M.; Willett, W.C. Should a low-fat, high-carbohydrate diet be recommended for everyone? Beyond low-fat diets. N. Engl. J. Med., 1997, 337(8), 563-566.
[PMID: 9262504]
Lissner, L.; Levitsky, D.A.; Strupp, B.J.; Kalkwarf, H.J.; Roe, D.A. Dietary fat and the regulation of energy intake in human subjects. Am. J. Clin. Nutr., 1987, 46(6), 886-892.
[http://dx.doi.org/10.1093/ajcn/46.6.886] [PMID: 3687822]
Bray, G.A.; Popkin, B.M. Dietary fat intake does affect obesity! Am. J. Clin. Nutr., 1998, 68(6), 1157-1173.
[http://dx.doi.org/10.1093/ajcn/68.6.1157] [PMID: 9846842]
Hurni, M.; Burnand, B.; Pittet, P.; Jequier, E. Metabolic effects of a mixed and a high-carbohydrate low-fat diet in man, measured over 24 h in a respiration chamber. Br. J. Nutr., 1982, 47(1), 33-43.
[http://dx.doi.org/10.1079/BJN19820006] [PMID: 7037049]
Acheson, K.J.; Schutz, Y.; Bessard, T.; Ravussin, E.; Jéquier, E.; Flatt, J.P. Nutritional influences on lipogenesis and thermogenesis after a carbohydrate meal. Am. J. Physiol., 1984, 246(1 Pt 1), E62-E70.
[PMID: 6696064]
Acheson, K.J.; Ravussin, E.; Wahren, J.; Jéquier, E. Thermic effect of glucose in man. Obligatory and facultative thermogenesis. J. Clin. Invest., 1984, 74(5), 1572-1580.
[http://dx.doi.org/10.1172/JCI111573] [PMID: 6389598]
Horton, T.J.; Drougas, H.; Brachey, A.; Reed, G.W.; Peters, J.C.; Hill, J.O. Fat and carbohydrate overfeeding in humans: different effects on energy storage. Am. J. Clin. Nutr., 1995, 62(1), 19-29.
[http://dx.doi.org/10.1093/ajcn/62.1.19] [PMID: 7598063]
Astrup, A.; Grunwald, G.K.; Melanson, E.L.; Saris, W.H.; Hill, J.O. The role of low-fat diets in body weight control: a meta-analysis of ad libitum dietary intervention studies. Int. J. Obes. Relat. Metab. Disord., 2000, 24(12), 1545-1552.
[http://dx.doi.org/10.1038/sj.ijo.0801453] [PMID: 11126204]
Lichtenstein, A.H.; Ausman, L.M.; Carrasco, W.; Jenner, J.L.; Ordovas, J.M.; Schaefer, E.J. Short-term consumption of a low-fat diet beneficially affects plasma lipid concentrations only when accompanied by weight loss. Hypercholesterolemia, low-fat diet, and plasma lipids. Arterioscler. Thromb., 1994, 14(11), 1751-1760.
[http://dx.doi.org/10.1161/01.ATV.14.11.1751] [PMID: 7947600]
Hooper, L.; Abdelhamid, A.; Moore, H.J.; Douthwaite, W.; Skeaff, C.M.; Summerbell, C.D. Effect of reducing total fat intake on body weight: systematic review and meta-analysis of randomised controlled trials and cohort studies. BMJ, 2012, 345e7666
[http://dx.doi.org/10.1136/bmj.e7666] [PMID: 23220130]
Astrup, A.; Ryan, L.; Grunwald, G.K.; Storgaard, M.; Saris, W.; Melanson, E.; Hill, J.O. The role of dietary fat in body fatness: evidence from a preliminary meta-analysis of ad libitum low-fat dietary intervention studies. Br. J. Nutr., 2000, 83(Suppl. 1), S25-S32.
[http://dx.doi.org/10.1017/S0007114500000921] [PMID: 10889789]
Willett, W.C. Dietary fat plays a major role in obesity: no. Obes. Rev., 2002, 3(2), 59-68.
[http://dx.doi.org/10.1046/j.1467-789X.2002.00060.x] [PMID: 12120421]
Dietary guidelines for healthy American adults. A statement for physicians and health professionals by the Nutrition Committee, American Heart Association. Circulation, 1988, 77(3), 721A-724A.
[PMID: 3342497]
Pelkman, C.L.; Fishell, V.K.; Maddox, D.H.; Pearson, T.A.; Mauger, D.T.; Kris-Etherton, P.M. Effects of moderate-fat (from monounsaturated fat) and low-fat weight-loss diets on the serum lipid profile in overweight and obese men and women. Am. J. Clin. Nutr., 2004, 79(2), 204-212.
[http://dx.doi.org/10.1093/ajcn/79.2.204] [PMID: 14749224]
Schaefer, E.J.; Lichtenstein, A.H.; Lamon-Fava, S.; McNamara, J.R.; Schaefer, M.M.; Rasmussen, H.; Ordovas, J.M. Body weight and low-density lipoprotein cholesterol changes after consumption of a low-fat ad libitum diet. JAMA, 1995, 274(18), 1450-1455.
[http://dx.doi.org/10.1001/jama.1995.03530180044028] [PMID: 7474191]
Vieira, V.J.; Valentine, R.J.; Wilund, K.R.; Antao, N.; Baynard, T.; Woods, J.A. Effects of exercise and low-fat diet on adipose tissue inflammation and metabolic complications in obese mice. Am. J. Physiol. Endocrinol. Metab., 2009, 296(5), E1164-E1171.
[http://dx.doi.org/10.1152/ajpendo.00054.2009] [PMID: 19276393]
Serra-Majem, L.; Román, B.; Estruch, R. Scientific evidence of interventions using the Mediterranean diet: a systematic review. Nutr. Rev., 2006, 64(2 Pt 2), S27-S47.
[http://dx.doi.org/10.1111/j.1753-4887.2006.tb00232.x] [PMID: 16532897]
Bray, G.A.; Lovejoy, J.C.; Smith, S.R.; DeLany, J.P.; Lefevre, M.; Hwang, D.; Ryan, D.H.; York, D.A. The influence of different fats and fatty acids on obesity, insulin resistance and inflammation. J. Nutr., 2002, 132(9), 2488-2491.
[http://dx.doi.org/10.1093/jn/132.9.2488] [PMID: 12221198]
Keys, A. Mediterranean diet and public health: personal reflections. Am. J. Clin. Nutr., 1995, 61(6)(Suppl.), 1321S-1323S.
[http://dx.doi.org/10.1093/ajcn/61.6.1321S] [PMID: 7754982]
Schröder, H. Protective mechanisms of the Mediterranean diet in obesity and type 2 diabetes. J. Nutr. Biochem., 2007, 18(3), 149-160.
[http://dx.doi.org/10.1016/j.jnutbio.2006.05.006] [PMID: 16963247]
Willett, W.C.; Sacks, F.; Trichopoulou, A.; Drescher, G.; Ferro-Luzzi, A.; Helsing, E.; Trichopoulos, D. Mediterranean diet pyramid: a cultural model for healthy eating. Am. J. Clin. Nutr., 1995, 61(6)(Suppl.), 1402S-1406S.
[http://dx.doi.org/10.1093/ajcn/61.6.1402S] [PMID: 7754995]
Bach-Faig, A.; Berry, E.M.; Lairon, D.; Reguant, J.; Trichopoulou, A.; Dernini, S.; Medina, F.X.; Battino, M.; Belahsen, R.; Miranda, G.; Serra-Majem, L. Mediterranean diet pyramid today. Science and cultural updates. Public Health Nutr., 2011, 14(12A), 2274-2284.
[http://dx.doi.org/10.1017/S1368980011002515] [PMID: 22166184]
Piers, L.S.; Walker, K.Z.; Stoney, R.M.; Soares, M.J.; O’Dea, K. Substitution of saturated with monounsaturated fat in a 4-week diet affects body weight and composition of overweight and obese men. Br. J. Nutr., 2003, 90(3), 717-727.
[http://dx.doi.org/10.1079/BJN2003948] [PMID: 13129479]
DeLany, J.P.; Windhauser, M.M.; Champagne, C.M.; Bray, G.A. Differential oxidation of individual dietary fatty acids in humans. Am. J. Clin. Nutr., 2000, 72(4), 905-911.
[http://dx.doi.org/10.1093/ajcn/72.4.905] [PMID: 11010930]
Soares, M.J.; Cummings, S.J.; Mamo, J.C.; Kenrick, M.; Piers, L.S. The acute effects of olive oil v. cream on postprandial thermogenesis and substrate oxidation in postmenopausal women. Br. J. Nutr., 2004, 91(2), 245-252.
[http://dx.doi.org/10.1079/BJN20031047] [PMID: 14756910]
McManus, K.; Antinoro, L.; Sacks, F. A randomized controlled trial of a moderate-fat, low-energy diet compared with a low fat, low-energy diet for weight loss in overweight adults. Int. J. Obes. Relat. Metab. Disord., 2001, 25(10), 1503-1511.
[http://dx.doi.org/10.1038/sj.ijo.0801796] [PMID: 11673773]
Esposito, K.; Maiorino, M.I.; Ciotola, M.; Di Palo, C.; Scognamiglio, P.; Gicchino, M.; Petrizzo, M.; Saccomanno, F.; Beneduce, F.; Ceriello, A.; Giugliano, D. Effects of a Mediterranean-style diet on the need for antihyperglycemic drug therapy in patients with newly diagnosed type 2 diabetes: a randomized trial. Ann. Intern. Med., 2009, 151(5), 306-314.
[http://dx.doi.org/10.7326/0003-4819-151-5-200909010-00004] [PMID: 19721018]
Elhayany, A.; Lustman, A.; Abel, R.; Attal-Singer, J.; Vinker, S. A low carbohydrate Mediterranean diet improves cardiovascular risk factors and diabetes control among overweight patients with type 2 diabetes mellitus: a 1-year prospective randomized intervention study. Diabetes Obes. Metab., 2010, 12(3), 204-209.
[http://dx.doi.org/10.1111/j.1463-1326.2009.01151.x] [PMID: 20151996]
Astrup, A. Dietary management of obesity. JPEN J. Parenter. Enteral Nutr., 2008, 32(5), 575-577.
[http://dx.doi.org/10.1177/0148607108321707] [PMID: 18753397]

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Year: 2019
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