PPARs in Neurodegenerative and Neuroinflammatory Pathways

Author(s): E. Benedetti, L. Cristiano, A. Antonosante, M. d'Angelo, B. d'Angelo, S. Selli, V. Castelli, R. Ippoliti, A. Giordano, A. Cimini*

Journal Name: Current Alzheimer Research

Volume 15 , Issue 4 , 2018

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Background: PPARs are lipid sensors activated by dietary lipids or their metabolites, mainly fatty acids and eicosanoids, that play critical roles in CNS biology, since brain has a very high lipid content and has the higher energetic metabolism in the body.

Methods: In neurodegenerative diseases in addition to metabolic impairment, also neuroinflammation is observed and PPARs are also closely linked to inflammatory processes. Several studies have revealed a complicated relationship between the innate immune response and tissue metabolism.

Results: In the brain, during pathological conditions, an alteration in metabolic status occurs, particularly involving glucose utilization and production, a condition which is generally related to metabolic changes.

Conclusion: Taking into account the high expression of PPARs in the brain, this review will focus on the role of these transcription factors in CNS diseases.

Keywords: Neurodegenetic disease, immune system, microglia cells, cytokines, neuroinflammation, neurons.

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Article Details

Year: 2018
Published on: 22 February, 2018
Page: [336 - 344]
Pages: 9
DOI: 10.2174/1567205014666170517150037
Price: $65

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