Bioactive Compounds and Diabetes
Pp. 200-229 (30)
Miriam Román Menacho, Domingo Ly Pen and Antonio Becerra Fernández
Diabetes mellitus (DM) is the most common endocrine disorder, and with a
very high development rate. There are two main groups of DM: type 1 DM (basically
due to an insulin deficiency), and type 2 DM (basically due to insulin resistance, i.e.:
there is plenty of insulin, but actually the cells are resistant to its action). Both types
lead to both abnormal glucose and lipids metabolism, sub-clinical inflammation and
higher oxidative stress. We will speak mainly about type 2 DM. Its genesis is
multifactorial, but we can ascertain that the diet is the principal modifiable factor. The
benefits of a healthy diet are not limited to its nutrient content, must also provide other
protective factors against oxidative stress, metabolic syndrome, diabetes and
carcinogenesis content especially in plant foods, called compounds bioactive, serving
in the body that can promote good health. A diet with high intake of phytochemicals
and rich in antioxidant capacity with polyphenolic compounds (as the Mediterranean
Diet), is related to a decreased risk of DM.
Beta cells, Diabetes, Insulin resistance, Mediterranean Diet,
Polyphenols, Prevention, Terpenes, Vitamins.
Clinical Biochemistry Department, Hospital Universitario Ramón y Cajal, Ctra, Colmenar km, 9,100, 28034, Madrid, Spain.