Progress of Trifluoroacetoacetate in the Synthesis of Agrochemicals and Medicines with Fluorine

Author(s): Yuechao Wu, Yulin Wang*, Mingping He, Xiaohong Tao, Jianguang Li, Danping Shan, Liang Lv*

Journal Name: Mini-Reviews in Organic Chemistry

Volume 14 , Issue 5 , 2017


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Abstract:

Fluorinated medicines have become research emphasis in the fields of pesticides and medicines due to their advanced properties. Trifluoroacetoacetate (TFAAE) is an important intermediate for the synthesis of pesticide, medicine and other fluorine compounds. As a useful building block containing trifluoromethyl, TFAAE is widely used in the synthesis of heterocyclic drugs, insecticides and herbicides. In this paper, the preparation methods of TFAAE and the advanced applications in agrochemicals and medicines with fluorine are introduced in detail

Keywords: Trifluoroacetoacetate, Ethyl 4, 4, 4-trifluoroacetoacetate, trifluoromethyl, agrochemicals, fluorine heterocyclic compound.

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Article Details

VOLUME: 14
ISSUE: 5
Year: 2017
Published on: 20 September, 2017
Page: [350 - 356]
Pages: 7
DOI: 10.2174/1570193X14666170511122820
Price: $65

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