Fluorinated medicines have become research emphasis in the fields of pesticides and medicines
due to their advanced properties. Trifluoroacetoacetate (TFAAE) is an important intermediate for
the synthesis of pesticide, medicine and other fluorine compounds. As a useful building block containing
trifluoromethyl, TFAAE is widely used in the synthesis of heterocyclic drugs, insecticides and herbicides.
In this paper, the preparation methods of TFAAE and the advanced applications in agrochemicals
and medicines with fluorine are introduced in detail
Keywords: Trifluoroacetoacetate, Ethyl 4, 4, 4-trifluoroacetoacetate, trifluoromethyl, agrochemicals, fluorine heterocyclic compound.
Rights & PermissionsPrintExport