A Mini Review on Synthetic Approaches and Biological Activities of Benzodiazepines

Author(s): Shweta Verma*, Sushil Kumar

Journal Name: Mini-Reviews in Organic Chemistry

Volume 14 , Issue 6 , 2017

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Graphical Abstract:


Background: Benzodiazepines (BDZs) are the bicyclic heterocyclic compounds in which benzene ring is fused to seven membered ring containing two nitrogen atoms. There are different types of BDZs such as 1, 2-benzodiazepines, 1, 3-benzodiazepines, 1, 4-benzodiazepines, 1, 5-benzodiazepines- 2, 3-benzodiazepines possess anxiolytic, anticonvulsant, antipsychotics, muscle relaxant and antimicrobial activities.

Method: Modifications and substitutions have been made in both rings by employing different methods to obtain a large number of BDZs. Due to their biological potentials the benzodiazepine nucleus has continued to attract many investigators to synthesize and screen their analogues for all possible biological activities.

Conclusion: This current review article describes the synthetic approaches and biological activities of benzodiazepines.

Keywords: Benzodiazepines, scaffold, bioactive, skeleton

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Article Details

Year: 2017
Published on: 16 November, 2017
Page: [453 - 468]
Pages: 16
DOI: 10.2174/1570193X14666170511121927
Price: $65

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PDF: 32
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