Background: Small scale robotics have attracted growing attention for the prospect of targeting
and accessing cell-sized sites, necessary for high precision biomedical applications and
drug/gene delivery. The loss of controlled gene therapy, inducing systemic side effects and reduced
therapeutic efficiency, can be settled utilizing these intelligent carriers.
Methods: Newly proposed solutions for the main challenges of control, power supplying, gene release
and final carrier extraction/degradation have shifted these smart miniature robots to the point of being
employed for practical applications of transferring oligonucleotides (pDNA, siRNA, mRNA, etc.) in
Conclusion: In this paper, different scenarios and their endeavors to address the vital working demands
and steps, in particular, carrier attachment and release, cell internalization, manipulation concerns
as well as actuation systems are discussed.This review highlights some promising experimental
results showing controlled gene release of robotic systems in comparison with current non-specific
gene delivery methods.