Design of Ru-arene Complexes for Antitumor Drugs

Author(s): Wei Su, Yuchun Li, Peiyuan Li*

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 18 , Issue 2 , 2018

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Abstract:

Recently, a number of promising ruthenium complexes have been investigated as anticancer drugs. Ru-arene complexes with [(η6-arene)Ru(X)(Y)(Z)] type, which exhibit a great structural variety, offer much potential in drug design. In this review we provide an overview of the progress in the field of arene ruthenium chemistry. We focus our attention particularly on the molecular structures and the anticancer applications of the Ru-arene complexes. Recent developments in the chemistry of arene ruthenium complexes will provide information for the investigation of novel anticancer organometallic drugs.

Keywords: Anticancer agent, antitumor, cytotoxicity, ruthenium-arene complexes, cell, inorganic compounds.

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Article Details

VOLUME: 18
ISSUE: 2
Year: 2018
Page: [184 - 193]
Pages: 10
DOI: 10.2174/1389557517666170510113453
Price: $65

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