Recently, a number of promising ruthenium complexes have been investigated as anticancer
drugs. Ru-arene complexes with [(η6-arene)Ru(X)(Y)(Z)] type, which exhibit a great structural variety,
offer much potential in drug design. In this review we provide an overview of the progress in the field
of arene ruthenium chemistry. We focus our attention particularly on the molecular structures and the
anticancer applications of the Ru-arene complexes. Recent developments in the chemistry of arene ruthenium
complexes will provide information for the investigation of novel anticancer organometallic
Keywords: Anticancer agent, antitumor, cytotoxicity, ruthenium-arene complexes, cell, inorganic compounds.
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