Background: On account of significant biological activities, quinoline derivatives have
drawn more attention to the synthesis and biological activities in the search for new therapeutic agents.
Several new synthetic approaches have been implemented to derive new molecules from quinoline and
all the synthesized molecules showed effective anticancer activity.
Method: Some molecules are synthesized using quinolones as precursor reactant, which is another effective
product of quinoline, also showing significant activity against malignant tumors. The presence of nitrogen
in it and its ability to bind with enzymes like gyrase, topoisomerase II and kinase have also
proven it with antitumor activity.
Conclusion: This review encapsulates the recent advances in the synthesis and anticancer activity of