Synthetic Methods of Quinoline Derivatives as Potent Anticancer Agents

Author(s): Vaibhav Sharma, Dinesh Kumar Mehta*, Rina Das

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 17 , Issue 16 , 2017


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Abstract:

Background: On account of significant biological activities, quinoline derivatives have drawn more attention to the synthesis and biological activities in the search for new therapeutic agents. Several new synthetic approaches have been implemented to derive new molecules from quinoline and all the synthesized molecules showed effective anticancer activity.

Method: Some molecules are synthesized using quinolones as precursor reactant, which is another effective product of quinoline, also showing significant activity against malignant tumors. The presence of nitrogen in it and its ability to bind with enzymes like gyrase, topoisomerase II and kinase have also proven it with antitumor activity.

Conclusion: This review encapsulates the recent advances in the synthesis and anticancer activity of Quinoline derivatives.

Keywords: Anticancer, anti-inflammatory, cancer, compounds, heterocyclic, quinoline, tumour.

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Article Details

VOLUME: 17
ISSUE: 16
Year: 2017
Published on: 05 October, 2017
Page: [1557 - 1572]
Pages: 16
DOI: 10.2174/1389557517666170510104954
Price: $65

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