Abstract
Fibrosis occurs in a variety of organs and frequently brings great harm to patients, even contributes to their death. Despite great efforts made in the field of fibrosis over the past decades and considerable understanding of the pathogenesis of fibrotic reactions attained, there is still lack of effective anti-fibrotic treatments. A growing body of evidence indicates a significant anti-fibrotic potential of activated soluble guanylate cyclase (sGC), which emphasizes the importance of sGC in fibrogenesis of diverse organs including skin, kidney, liver and lung. While sGC has been well known for its role in the regulation of vascular tone and vascular remodeling, its possible implication in fibrosis remains to be illustrated. Emerging evidence in recent years provides new insights into anti-fibrotic effect of sGC stimulation by blocking non-canonical TGF-β signaling. In this review we will discuss the key role of sGC and its mechanism of action in fibrosis. Herein, sGC signaling pathway may represent a promising target for treating tissue fibrosis.
Keywords: Fibrotic diseases, soluble guanylate cyclase, TGF-β signaling pathway, extracellular regulated protein kinases, soluble guanylate cyclase modulators, mechanism of action.
Current Medicinal Chemistry
Title:Soluble Guanylate Cyclase: A New Therapeutic Target for Fibrotic Diseases
Volume: 24 Issue: 29
Author(s): Liqing Hu, Zeyu Wang, Rui Yi , Honghong Yi , Sijia Xiao, Zhuo Chen , Gaoyun Hu and Qianbin Li *
Affiliation:
- Department of Medicinal Chemistry, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013,China
Keywords: Fibrotic diseases, soluble guanylate cyclase, TGF-β signaling pathway, extracellular regulated protein kinases, soluble guanylate cyclase modulators, mechanism of action.
Abstract: Fibrosis occurs in a variety of organs and frequently brings great harm to patients, even contributes to their death. Despite great efforts made in the field of fibrosis over the past decades and considerable understanding of the pathogenesis of fibrotic reactions attained, there is still lack of effective anti-fibrotic treatments. A growing body of evidence indicates a significant anti-fibrotic potential of activated soluble guanylate cyclase (sGC), which emphasizes the importance of sGC in fibrogenesis of diverse organs including skin, kidney, liver and lung. While sGC has been well known for its role in the regulation of vascular tone and vascular remodeling, its possible implication in fibrosis remains to be illustrated. Emerging evidence in recent years provides new insights into anti-fibrotic effect of sGC stimulation by blocking non-canonical TGF-β signaling. In this review we will discuss the key role of sGC and its mechanism of action in fibrosis. Herein, sGC signaling pathway may represent a promising target for treating tissue fibrosis.
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Cite this article as:
Hu Liqing , Wang Zeyu , Yi Rui , Yi Honghong, Xiao Sijia, Chen Zhuo , Hu Gaoyun and Li Qianbin *, Soluble Guanylate Cyclase: A New Therapeutic Target for Fibrotic Diseases, Current Medicinal Chemistry 2017; 24 (29) . https://dx.doi.org/10.2174/0929867324666170509115433
DOI https://dx.doi.org/10.2174/0929867324666170509115433 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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