Title:Boehmite Silylpropyl Amine Sulfamic Acid as an Efficient and Recyclable Catalyst for the Synthesis of some Pyrazole Derivatives
VOLUME: 14 ISSUE: 6
Author(s):Rahele Doosti, Mohammad Bakherad*, Mahdi Mirzaee* and Khosrow Jadidi
Affiliation:School of Chemistry, Shahrood University of Technology, Shahrood 3619995161, School of Chemistry, Shahrood University of Technology, Shahrood 3619995161, School of Chemistry, Shahrood University of Technology, Shahrood 3619995161, Department of Chemistry, Shahid Beheshti University, Tehran 1983963113
Keywords:Boehmite nanoparticle, reusable catalyst, sulfamic acid, pyrazoles.
Abstract:Background: The design of biologically-active compounds is a challenging viewpoint in
medicinal chemistry, and pyrazoles play a crucial role as biologically-active molecules.
Methods: Up to now, a few examples have been reported for the synthesis of pyrazoles catalyzed by
heterogeneous catalysts. In this work, a new boehmite silylpropyl amine sulfamic (m-SABNPs) was
applied as a catalyst for one-pot synthesis of pyrazole derivatives.
Results: It was found that this heterogeneous sulfamic acid is a highly efficient catalyst for the syntheses
of 5-amino-1,3-aryl-1H-pyrazole-4-carbonitriles and pyrazolopyranopyrimidines in good to excellent
yields and can be recovered by a simple filtration of the reaction solution and reused for five consecutive
runs without significant loss of catalytic activity. Moreover, its structure was characterized by
FT-IR spectroscopy, TGA, XRD, TEM and SEM techniques.
Conclusion: An efficient, and convenient method was proposed for the synthesis of pyrazole derivatives
catalyzed by heterogeneous sulfamic acid in high-to-excellent yields. This method offers several
advantages like milder reaction condition, shorter reaction time, cleaner reaction, and reusability of the
catalyst.
