Background: The primary roles of mesenchymal stem cells (MSCs) are to maintain the stem
cell niche, facilitate recovery after injury, and ensure healthy aging and the homeostasis of organ and
tissues. MSCs have recently emerged as a new therapeutic option for hair loss.
Objective: Since adipose-derived stem cells (ADSCs) are the most accessible sources of MSCs, ADSCbased
hair regeneration is investigated. Besides replacing degenerated cells in affected organs, ADSCs
exhibit their beneficial effects through the paracrine actions of various cytokines and growth factors.
Results: Several laboratory experiments and animal studies have shown that ADSC-related proteins
can stimulate hair growth. In addition, we introduce our clinical pilot studies using conditioned media
of ADSCs for pattern hair loss in men and women.
Conclusion: We believe that conditioned media of ADSCs represents a promising alternative therapeutic
strategy for hair loss. We also discuss practical therapeutic challenges and the direction of future