Nanotechnology: A Promising Tool Towards Wound Healing

Author(s): Thais Alberti, Daniela S. Coelho, Ana Voytena, Heloisa Pitz, Manuel de Pra, Leticia Mazzarino, Shirley Kuhnen, Rosa M. Ribeiro-do-Valle, Marcelo Maraschin, Beatriz Veleirinho*

Journal Name: Current Pharmaceutical Design

Volume 23 , Issue 24 , 2017


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Abstract:

Nanotechnology is an exciting emerging field with multiple applications in skin regeneration. Nanofibers have gained special attention in skin regeneration based on their structural similarity to the extracellular matrix. A wide variety of polymeric nanofibers with distinct properties have been developed and tested as scaffolds for skin regeneration. Besides providing support for tissue repair, nanofibrous materials can act as delivery systems for drugs, proteins, growth factors, and other molecules. Moreover, the morphology, biodegradability, and other functionalities of nanofibrous materials can be controlled towards specific conditions of wound healing. Other nanostructured drug delivery systems, such as nanoparticles, micelles, nanoemulsions, and liposomes, have been used to improve wound healing at different stages. These nanoscale delivery systems have demonstrated several benefits for the wound healing process, including reduced cytotoxicity of drugs, administration of poorly water-soluble drugs, improved skin penetration, controlled release properties, antimicrobial activity, and protection of drugs against light, temperature, enzymes or pH degradation, as well as stimulation of fibroblast proliferation and reduced inflammation.

Keywords: Wound healing, nanofibers, nanoparticles, nanostructured drug delivery systems, nanoemulsions, liposomes, cyclodextrins, micelles.

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Article Details

VOLUME: 23
ISSUE: 24
Year: 2017
Published on: 03 May, 2017
Page: [3515 - 3528]
Pages: 14
DOI: 10.2174/1381612823666170503152550
Price: $65

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