Nanotechnology is an exciting emerging field with multiple applications in skin regeneration. Nanofibers
have gained special attention in skin regeneration based on their structural similarity to the extracellular
matrix. A wide variety of polymeric nanofibers with distinct properties have been developed and tested as scaffolds
for skin regeneration. Besides providing support for tissue repair, nanofibrous materials can act as delivery
systems for drugs, proteins, growth factors, and other molecules. Moreover, the morphology, biodegradability,
and other functionalities of nanofibrous materials can be controlled towards specific conditions of wound healing.
Other nanostructured drug delivery systems, such as nanoparticles, micelles, nanoemulsions, and liposomes, have
been used to improve wound healing at different stages. These nanoscale delivery systems have demonstrated
several benefits for the wound healing process, including reduced cytotoxicity of drugs, administration of poorly
water-soluble drugs, improved skin penetration, controlled release properties, antimicrobial activity, and protection
of drugs against light, temperature, enzymes or pH degradation, as well as stimulation of fibroblast proliferation
and reduced inflammation.