Medicinal Plants as Immune Response Enhancers to Prevent Infectious Diseases of Veterinary Interest
Pp. 132-149 (18)
Laura Noelia Cariddi, Ivana Dalila Montironi and Elina Beatriz Reinoso
Mastitis is considered worldwide as the disease of cattle that causes severe
economic losses in dairy industry worldwide and is usually associated with the
presence of infectious agents as bacteria. Bacterial pathogens have been classified in
contagious, environmental and opportunistic pathogens. Antibiotic therapy is one of the
routine treatments for mastitis. However, antibiotics are moderately effective and their
indiscriminate use leads to resistant strains. In addition, residues remain in milk with
implications for human health.
Therefore, one of the objectives of the dairy industry is to reduce the use of antibiotics
in animals food producing. The mammary gland has defense mechanisms against
The incidence of mastitis increases when these mechanisms are impaired.
Polymorphonuclear neutrophils (PMN), macrophages and lymphocytes play a very
important role in the defense against mastitis. These cells regulate both the innate and
adaptive response. Alternative therapies are conducted in order to both reinforce the
antimicrobial therapy and to increase the natural defenses of the mammary gland. The
application of immunomodulatory compounds to stimulate the immune response of the
mammary gland is one of the most innovative alternative strategies studied today.
In this context, immunomodulators compounds derived from medicinal plants appear
as an effective alternative therapy. Several studies have reported that ginseng saponins
or ginsenosides of Panax ginseng, extracts of Tinospora cordifolia or Taraxacum
mongolicum, flavonoids of Rosa agrestis among others, have stimulatory effects on
immune response of the mammary gland with potential use in the treatment of bovine mastitis. Strategies to enhance the immune response of the udder will heavily impact
the animals’ ability to resist pathogen infection.
Active Metabolites, Alternative Therapy, Bovine Mastitis, Cattle,
Control of Infection Diseases, Immunomodulators, Intramammary Infections,
Immune response, Microbial Agents, Medicinal Plants.
CONICET. Departamento de Microbiología e Inmunología, Universidad Nacional de Río Cuarto, Ruta 36 Km 601, CP 5800, Río Cuarto, Córdoba, Argentina.