Vitamin D Metabolism and Potential Effects of Vitamin D Receptor Modulation in Chronic Kidney Disease

Author(s): Antonio Bellasi*, Andrea Galassi, Michela Mangano, Luca Di Lullo, Mario Cozzolino

Journal Name: Current Drug Metabolism

Volume 18 , Issue 7 , 2017

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Graphical Abstract:


Background: Vitamin D deficiency is one determinant of secondary hyperparathyroidism in the course of Chronic Kidney Disease (CKD). However, numerous studies support the notion that vitamin D may exert pleiotropic effects aside of mineral metabolism control. Indeed, vitamin D receptor has been identified in a great variety of tissues and its activation contributes to the parathyroid, intestine, cardiovascular and immune system regulation.

Conclusion: We herein review vitamin D metabolism and effects with a specific emphasis on the potential impact of vitamin D receptor modulation aside from parathyroid hormone control.

Keywords: CKD-MBD, vitamin D, paracalcitol, Vitamin D receptor, vitamin D deficiency.

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Article Details

Year: 2017
Published on: 06 September, 2017
Page: [680 - 688]
Pages: 9
DOI: 10.2174/1389200218666170427112735
Price: $65

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