Introduction: Systemic Sclerosis is known to involve the gastrointestinal system and can
lead to multitude of problems predominantly affecting the GI motility.
Methods: It was a prospective, observational, single centre study of fifty consecutive patients with
SSc who presented to rheumatology clinic. Gut score was assessed using UCLA SCTC GIT 2.0
questionnaire. 35 patients underwent esophago- gastro duodenoscopy(UGIE), 31 underwent esophageal
manometry, 37 underwent lactulose breath test to assess orocaecal transit time (OCTT) and
glucose breath test for detecting small intestinal bacterial overgrowth (SIBO) and 36 underwent
gastric emptying scintigraphy to measure gastric emptying time.
Results: GI involvement was seen in 98% of patients, with most common symptom being regurgitation
(78%). Mean T score of the GUT score was 0.60±0.27. In UGIE, esophagitis was seen in 30,
of which 3 had candidiasis and 1 had HSV esophagitis. Hiatus hernia was noted in 10 patients.
Mean lower esophageal sphincter pressure was 16.1± 12.7 mmHg with hypotensive sphincture in
twelve patients. Esophageal peristaltic abnormalities were observed in 28(90%) patients. Gastric
emptying was delayed in10/36 patients. OCTT was prolonged in 23/ 37 patients whereas SIBO was
noted in 7/37.
Conclusion: GI involvement is common in SSc with esophagus being most commonly affected.
Motility abnormalities make them prone for super added infections especially infectious esophagitis
and SIBO and should be investigated for early detection and treatment.