Background: Quaternary α-amino acids with a tetrasubstituted carbon stereocenter have a
variety of biological activities. Due to the steric hindrance of the quaternary carbon centers, highly efficient
asymmetric catalytic synthesis is greatly challenging.
Objective: In this paper, with a focus on the asymmetric formation of chemical bonds in reactions, the
asymmetric catalytic synthesis of quaternary α-amino acids in recent years is reviewed.
Conclusion: Several representative catalytic asymmetric reactions are introduced, and the effects of different
catalysts on the reaction results are discussed.