New Progress in Asymmetric Synthesis of Quaternary α-Amino Acids

Author(s): Han Jiang, Yi Jin*, Jun Lin*

Journal Name: Mini-Reviews in Organic Chemistry

Volume 14 , Issue 6 , 2017


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Abstract:

Background: Quaternary α-amino acids with a tetrasubstituted carbon stereocenter have a variety of biological activities. Due to the steric hindrance of the quaternary carbon centers, highly efficient asymmetric catalytic synthesis is greatly challenging.

Objective: In this paper, with a focus on the asymmetric formation of chemical bonds in reactions, the asymmetric catalytic synthesis of quaternary α-amino acids in recent years is reviewed.

Conclusion: Several representative catalytic asymmetric reactions are introduced, and the effects of different catalysts on the reaction results are discussed.

Keywords: Quaternary a-amino acids, asymmetric catalytic synthesis, quaternary stereocenters, formation of C-C bond, formation of C-N bond, asymmetric alkylation reaction.

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Article Details

VOLUME: 14
ISSUE: 6
Year: 2017
Published on: 16 November, 2017
Page: [434 - 447]
Pages: 14
DOI: 10.2174/1570193X14666170420121255
Price: $65

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