Development of a Chitosan-based Nanoparticle Formulation for Ophthalmic Delivery of Honokiol

Author(s): Feng Deng, Wenjing Hu, Huali Chen, Yalan Tang, Liangke Zhang*

Journal Name: Current Drug Delivery

Volume 15 , Issue 4 , 2018

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Graphical Abstract:


Background: Retinal neovascularization (NV) is the leading cause of blindness in the majority of ocular diseases. Several treatment approaches have been developed for retinal NV; of these methods, instillation of nanoparticles into the conjunctival sac has shown potential for retinal NV treatment because it does not cause physical damage and is easy to operate.

Methods: In this study, honokiol-loaded chitosan/sulfobutylether-β-cyclodextrin nanoparticles (HKCS- NPs) were prepared for ophthalmic drug delivery systems. An inclusion complex of honokiol and sulfobutylether-β-cyclodextrin was used to incorporated insoluble honokiol into chitosan nanoparticles, which were prepared through ionotropic gelation.

Results: HK-CS-NPs featured a spherical surface with a narrow size distribution of polydispersity index less than 0.250, a mean size range of 373–523 nm, a positive surface charge of +19.9 to +24.2 mV, and an entrapment efficiency of 84.92%. In vitro release studies showed an initial burst release phase and a sustained release phase of nanoparticles. Moreover, in vivo study showed that HK-CS-NPs exhibited good ocular tolerability and could improve ophthalmic bioavailability of honokiol. In particular, the maximum concentration of honokiol after administration of HK-CS-NPs was enhanced by 1.65 times compared with that after instillation of the honokiol suspension alone.

Conclusion: This study proposes HK-CS-NPs as a potential ophthalmic delivery system.

Keywords: Chitosan, honokiol, nanoparticles, ocular drug delivery, retinal neovascularization, sulfobutylether-β-cyclodextrin.

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Article Details

Year: 2018
Published on: 16 April, 2018
Page: [594 - 600]
Pages: 7
DOI: 10.2174/1567201814666170419113933
Price: $65

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