Objective: Alzheimer's disease (AD), the most important progressive neurodegenerative disorder,
is characterized by cognitive and behavioral disabilities. Nowadays, tau, as a microtubuleassociated
protein and a principle neuropathological hallmark of AD, provides us a neoteric perspective
to explore further aetiopathogenesis and therapeutic strategy. The hyperphosphorylation and abnormal
aggregation of tau, combined with its decreased clearance, form neurofibrillary tangles (NFTs) and exert
neurotoxicity in AD.
Methods: Recent investigations aim to prevent the deposition of NFT and accelerate the clearance of
NFT. Intriguingly, immunization strategies targeting tau effectively ameliorates the tau-associated pathology
in AD. In addition, modified therapies targeting tau should be regarded as a potential way to
treat AD. These progresses open new avenues for AD.
Conclusion: Here, we review the recent literature of potential mechanisms of the tau in AD and discuss
the modified therapeutic strategies for AD.