Therapeutic Applications of Liposomal Based Drug Delivery and Drug Targeting for Immune Linked Inflammatory Maladies: A Contemporary View Point

Author(s): Mahfoozur Rahman*, Sarwar Beg, Amita Verma, Imran Kazmi, Dinesh Kumar Patel, Firoz Anwar, Fahad A Al Abbasi, Vikas Kumar*

Journal Name: Current Drug Targets

Volume 18 , Issue 13 , 2017

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Graphical Abstract:


Immune-based inflammatory diseases involve immune related dysregulation in different sites of body, which includes rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease, atherosclerosis, etc. Advancements in molecular research have facilitated investigation of their pathogenesis that is involved in inflammatory cytokines cells and several genes. The available drug therapy provides suboptimal therapeutic effects and higher adverse effects. Emergence of liposomal systems of the drugs meant for the above mentioned disease has gained broader importance due to their high treatment efficacy by means of optimal therapeutic drug delivery. Beyond the conventional liposomal formulations, evolution of second generation liposomes including stealth liposomes, cationic liposomes, immuno-liposomes, etc. has gained tremendous attention owing to their drug target potential, diagnostic importance and imaging in treatment of above mentioned immune mediated inflammatory disorders.

Keywords: Immune mediated inflammatory disorders, liposomes, cationic liposomes, immuno-liposomes, atherosclerosis, multiple sclerosis.

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Article Details

Year: 2017
Page: [1558 - 1571]
Pages: 14
DOI: 10.2174/1389450118666170414113926
Price: $65

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PDF: 40