Potential Molecular Targets of Ampelopsin in Prevention and Treatment of Cancers

Author(s): Xianjuan Kou, Jingjing Fan, Ning Chen*

Journal Name: Anti-Cancer Agents in Medicinal Chemistry
(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)

Volume 17 , Issue 12 , 2017

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Graphical Abstract:


Cancers have increased threat to human health due to the limited treatment efficacy of chemotherapy and radiotherapy with a series of toxicity and side effects; therefore, the development and utilization of natural products with potential preventive and therapeutic efficacy, and less toxicity and side effects will be beneficial to promote the health of cancer patients. In this article, the activity of ampelopsin as a natural flavonoid and its underlying molecular mechanisms for the prevention and treatments of hepatic carcinoma, breast cancer, prostate cancer and melanoma through inhibiting cell proliferation, accelerating apoptosis, inducing reactive oxygen species (ROS) generation and endoplasmic reticulum (ER) stress, suppressing angiogenesis, invasion and metastasis, and synergizing the efficacy of other anti-cancer drugs have been summarized. This study will provide a reference for the development and utilization of other natural products.

Keywords: Natural product, ampelopsin, chemotherapy, signal pathway, molecular mechanism, cancer.

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Article Details

Year: 2017
Published on: 16 January, 2018
Page: [1610 - 1616]
Pages: 7
DOI: 10.2174/1871521409666170412130529
Price: $65

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