Non-conventional Green Strategies for NHC Catalyzed Carbon-Carbon Coupling Reactions

Author(s): Majid M. Heravi*, Bahareh Heidari, Mahdieh Ghavidel, Tahereh Ahmadi

Journal Name: Current Organic Chemistry

Volume 21 , Issue 22 , 2017

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Graphical Abstract:


Background: Coupling reactions, commonly can be achieved via a wide range of organometallic reagents and electrophiles, representing an important class of synthetic transformation, namely “cross-coupling reaction. It is frequently catalyzed by various palladium (Pd) as species. The synthesis and characterization of an N-heterocyclic carbine (NHC) was accomplished in 1991. In 1991, the first synthesis of a stable NHC was achieved and reported.

Objective: This development literally invigorated the interest and attention for this novel species being examined as a ligand for the synthesis of Pd Complexes.

Conclusion: In this review, we tried to give a full account on the development of NHC–Pd chemistry intended being used as catalyst under non-conventional conditions. In this light, those carbon-carbon bond formations being successfully achieved in aqueous systems, using immobilized NHC-Pd complexes under nonconventional strategies, such as being conducted under microwave irradiations (MWI) are supported and solvent- free conditions are discussed.

Keywords: Cross-Coupling Reactions, N-Heterocyclic Carbene (NHC), green chemistry, microwave irradiation, aqueous media, Pdcatalyzed reaction, suzuki reaction, heck reaction.

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Article Details

Year: 2017
Page: [2249 - 2313]
Pages: 65
DOI: 10.2174/1385272821666170410103712
Price: $58

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