Background: H1N1 (hemagglutinin-H-neuroaminidase-N) influenza infection
is associated with high morbidity and mortality because of associated complications
and related factors. Predictors of mortality in H1N1 patients are studied
with very few without seasonal/pandemic declaration. This study was carried out to
describe the clinical features, complications and different risk factors that affect the
outcome in the patients with confirmed H1N1influenza infection.
Methods: A retrospective study was done in Kasturba Medical College Hospital,
Manipal, India by analyzing the medical records of 141 patients admitted from January,
2011 to June, 2015.
Results: Of the 141 patients in the study, 51.1% of the patients were female with a
mean age of 32±16.2 years. Fever with headache was observed in 92.9% patients
while cough in 78.7% patients and breathlessness in 54.6% patients. On the basis of
disease severity, 53.2% of the patients were put on mechanical ventilation. For all the
patients, treatment for influenza management began with oseltemivir. Diuretics, antianxiety
and corticosteroids were given as supportive and symptomatic care which
contributed to high mortality in hospitalized patients. Mean hospitalization period
was 8.5 days. During the hospitalization, patients developed different complications
i.e. 31.20% patients developed respiratory tract infections, while 17.7% patients developed
ARDS and 14.4% patients developed sepsis. The mortality rate of this study
population was found to be 29.1 %.
Conclusion: It was observed that low oxygen saturation during admission, high
blood urea level, use of diuretics, corticosteroids, anti-anxiety drugs and complications
like ARDS, sepsis influence the mortality rate of patients with H1N1 infection.