Title:Relationship of High-Sensitivity C-Reactive Protein Concentrations and Systolic Heart Failure
VOLUME: 15 ISSUE: 4
Author(s):Sheng Kang*, Lie-Ying Fan, Ming Chen, Jue Li and Zhong-Min Liu
Affiliation:Center of Cardiology, Shanghai East Hospital, Tongji University, Jimo Rd 150, 200120, Shanghai, Department of Clinical Laboratory, Shanghai East Hospital, Tongji University, Shanghai, Department of Cardiac Ultrasound, Shanghai East Hospital, Tongji University, Shanghai, Department of Epidemiology, Tongji University School of Medical, Shanghai, Center of Cardiology, Shanghai East Hospital, Tongji University, Shanghai
Keywords:High-sensitivity C-reactive protein, systolic heart failure, fasting blood sugar, total cholesterol.
Abstract:Objective:
Excessive activated proinflammatory cytokines may promote extracellular
matrix alterations which induce adverse left ventricular remodeling in
systolic heart failure (SHF). We sought to identify whether high-sensitivity
C-reactive protein (hsCRP) levels were independently associated with SHF.
Methods:
In our retrospective case-control study, 2236 subjects were included, and
260 patients had SHF. Blood sample collection, clinical laboratory tests,
electrocardiogram and echocardiography examinations were performed. The
questionnaires were completed by professional interviews.
Results:
In 2236 subjects, the prevalence rate of SHF were 1.7, 1.8, 8.4 and 32.6%
between hsCRP concentrations (<1 mg/L, ≥1 to <3 mg/L, ≥3 to <10 mg/L and
≥10 mg/L, respectively) (p=0.000). hsCRP concentrations (<1 mg/L, ≥1 to
<3 mg/L, ≥3 to <10 mg/L and ≥10 mg/L) were associated in a linear trend
with N-terminal pro-brain natriuretic peptide (NT-proBNP, p=0.000) and left
ventricular ejection fraction (LVEF, p=0.000). hsCRP was also significantly
related to NT-proBNP, LVEF and SHF (r=0.232, p=0.000; r=-0.358, p=0.000 and
r=0.413, p=0.000, respectively). In logistic regression model, after
adjusting for heart failure risk factors, compared with the low
concentration of hsCRP (<1 mg/L), the high concentration of hsCRP (≥10
mg/L) was significantly independently associated with SHF (odds ratio =
10.78 [1.303 to 89.10], p=0.027).
Conclusion:
Low to high concentration of hsCRP showed a linear trend association with
SHF. A high concentration of hsCRP was independently associated with SHF.
