Targeting Malassezia species for Novel Synthetic and Natural Antidandruff Agents

Author(s): Letizia Angiolella, Simone Carradori*, Cristina Maccallini, Gustavo Giusiano, Claudiu T. Supuran

Journal Name: Current Medicinal Chemistry

Volume 24 , Issue 22 , 2017

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Malassezia spp. are lipophilic yeasts not only present in the normal skin microflora, but also responsible of skin-related diseases (pityriasis versicolor, seborrheic/atopic dermatitis and dandruff) as well as systemic fungal infections in humans and animals. Their treatment and eradication are mainly based on old azole drugs, which are characterized by poor compliance, unpredictable clinical efficacy, emerging resistance and several side effects. These drawbacks have prompted the research toward novel synthetic and natural derivatives/ nanomaterials targeting other pivotal enzymes/pathways such as carbonic anhydrase (MgCA) and lipases, alone or in combination, in order to improve the eradication rate of this fungus. This review accomplished an update on this important topic dealing with the latest discoveries of synthetic scaffolds and natural products for the treatment of Malasseziaspp.-related diseases, thus suggesting new opportunities to design innovative and alternative anti-dandruff drugs.

Keywords: Azoles, carbonic anhydrase inhibitors, dandruff, lipase inhibitors, Malassezia spp., natural inhibitors.

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Article Details

Year: 2017
Published on: 23 August, 2017
Page: [2392 - 2412]
Pages: 21
DOI: 10.2174/0929867324666170404110631
Price: $65

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