Background: Recently, pyrimidine and chromene derivatives have concerned increasing attention
because of the wide range of biological activities. Considering the prominence of pyrimidine
and chromene derivatives, several procedures have been reported for the synthesis of these compounds.
Herein, new magnetic nanoparticles supported ionic liquid has been evaluated for the synthesis
of pyrimidine and chromene derivatives.
Methods: In this method, pyrimidine and chromene compounds were synthesized by the multicomponent
reaction of aromatic aldehydes, malononitrile, and active methylene compounds in the presence
of the new magnetic nanoparticles supported ionic liquid. The new nanocatalyst was characterized
by using TEM, VSM, XRD and IR spectrum.
Results: The remarkable advantages of this new procedure involve high yields, short experimental time,
low cast and easy preparation of the catalyst and no need of any workup and purification. Magnetic properties
of the catalyst led to the easy separation from the reaction mixture by using an external magnet.
The catalyst can be reused several times in the desired reaction without significant decrease of its activity.
Conclusion: An efficient and green method for the synthesis of chromene and pyrimidine compounds
in the presence of magnetic nanoparticles supported ionic liquid have been developed. Thermal stability,
low cost and easy synthesis of the catalyst, high yields, easy separation and purification of the product,
short experimental time and using a green solvent such as water provided a useful and alternative
method for such reactions.