Title:Amberlyst-15® in PEG-400: Green Synthesis of 3-Benzoyl-5-Hydroxy Benzofuran and Naphtho[1,2-b]furan Derivatives at Room Temperature
VOLUME: 14 ISSUE: 5
Author(s):Surendra Bose Bathula*, Mukkanti Khagga and Hariharakrishnan Venkatasubramanian
Affiliation:Alekya Drugs Pvt. Ltd, R&D Division, Plot No: 145-150, Vijayawada, Andhra Pradesh, Chemistry Division, Institute of Science and Technology, JNT University, Kukatpally, Hyderabad-500 072, Telangana, RA Chem Pharma Ltd., Plot No. 26 & 27, Technocrats Industrial Estate, Balanagar, Hyderabad-500 037
Keywords:Amberlyst-15®, benzofurans and naphthofurans, green synthesis, intramolecular cyclization, michael addition.
Abstract:Background: Oxygen heterocycles exhibit diverse biological and pharmacological activities.
In particular, benzofurans are available in a wide number of natural products and have drawn considerable
attention over the last few years due to their profound physiological and biological properties.
The aim of this paper describes a green methodology to synthesize this potent molecule with high
selectivity by using ionic resin in PEG at room temperature.
Methods: The methodology is very simple and easily accessible at room temperature. It uses low catalyst
loadings and is recycled subsequently. In addition, detailed experimental procedure for the selected compounds
including the spectral data are provided.
Results: Among the various ionic resins attempted, Amberlyst-15® in PEG-400 was the choice of selection
for the synthesis of 3-benzoyl-5-hydroxy benzofuran and naphtho[1,2-b]furan derivatives at
room temperature in an environmentally friendly method. This catalyst system resulted in excellent
yields in short reaction times and high selectivity.
Conclusion: We have developed a green highly efficient and environmentally friendly protocol for the
facile synthesis of 3-benzoyl-5-hydroxy benzofuran and naphtho[1,2-b]furan derivatives at room temperature
in high yields (>90-95%) using nontoxic and inexpensive ion exchange resin Amberlyst-15®.
The notable advantages of the catalyst approach enables the reactions with high selectivity, short reactions
time and excellent yields without generating any waste and was reused.
