Synthesis and Antimicrobial Activity of Some Novel Substituted 3-(Thiophen-2-yl)pyrazole-based Heterocycles

Author(s): Bakr F. Abdel-Wahab*, Abdelbasset A. Farahat, Ghada E. A. Awad, Gamal A. El-Hiti*

Journal Name: Letters in Drug Design & Discovery

Volume 14 , Issue 11 , 2017

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Graphical Abstract:


Background: A series of novel substituted 3-(thiophen-2-yl)pyrazoles was synthesized efficiently and in high yields using simple and convenient procedures starting from 1-phenyl-3- (thiophen-2-yl)-1H-pyrazole-4-carbaldehyde.

Methods: The structures of the newly synthesized products were established and their antimicrobial activities were investigated against some bacteria and fungi.

Results and Conclusion: The products showed excellent antimicrobial activities against the tested microorganism compared to the standard antibacterial and antifungal drugs.

Keywords: Drug design, antimicrobial activity, microorganisms, 3-(thiophen-2-yl)pyrazoles, hydrazides, inhibition zone.

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Article Details

Year: 2017
Published on: 02 October, 2017
Page: [1316 - 1323]
Pages: 8
DOI: 10.2174/1570180814666170327162447
Price: $65

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