Title:Body Fluids-Derived Exosomes: Paving the Novel Road to Lung Cancer Diagnosis and Therapy
VOLUME: 17 ISSUE: 13
Author(s):Yu Sun, Lin Li, Liang Wang and Jing Liu*
Affiliation:Regenerative Medicine Centre, First Affiliated Hospital of Dalian Medical University, Dalian, 116011, Regenerative Medicine Centre, First Affiliated Hospital of Dalian Medical University, Dalian, 116011, Regenerative Medicine Centre, First Affiliated Hospital of Dalian Medical University, Dalian, 116011, Regenerative Medicine Centre, First Affiliated Hospital of Dalian Medical University, Dalian, 116011
Keywords:Exosomes, biomarkers, diagnosis, therapy, cancer floids-derived, lung.
Abstract:Lung cancer is a major human malignancy. Nowadays, the lack of specific diagnostic markers of lung
cancer restricts the early diagnosis and therapy of patients. Exosomes, as spherical 30-100 nm microvesicles, are
released by normal and cancer cells in both physiological and pathological circumstances. Exosomes carry various
molecular cargos such as miRNA, proteins, mRNA, DNA and lipids. Therefore, analysis of the molecular
profiles of exosomes may provide beneficial biomarkers for disease diagnosis. Exosomes can be transported by
body fluids. The molecules (miRNAs and proteins) detected in body fluid exosomes may contribute to lung
cancer diagnosis. In this review, we summarize typical molecules (miRNAs and proteins) in body fluids-derived
exosomes to reveal the potential biomarkers in lung cancer. Besides, the role and the application of exosomes in
chemotherapy and radiotherapy of lung cancer patients have also been discussed in this review.
