Low Dose Naltrexone in the Treatment of Fibromyalgia

Author(s): Samy Metyas*, Christina L. Chen, Karen Yeter, John Solyman, Daniel G. Arkfeld

Journal Name: Current Rheumatology Reviews

Volume 14 , Issue 2 , 2018

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Graphical Abstract:


Background: ConclusionFibromyalgia is a chronic pain disorder characterized by diffuse musculoskeletal pain, fatigue, sleep disturbance and cognitive impairment.

Objective: A significant number of fibromyalgia patients do not respond adequately to the current drugs approved by the Food and Drug Administration (FDA) for fibromyalgia treatment including pregabalin, milnacipran, duloxetine. Thus, there is still a need for adjunctive therapies.

Method: Naltrexone is an opioid receptor antagonist used to treat alcohol and opioid dependence. It is hypothesized that low dose naltrexone causes transient blockade of opioid receptors centrally resulting in a rebound of endorphin function which may attenuate pain in fibromyalgia.

Results: Two small prospective pilot studies have previously shown that treatment with low dose naltrexone may be an effective, safe, and inexpensive treatment for fibromyalgia.

Conclusion: This prospective study lends further support to the preliminary body of evidence that naltrexone is a well tolerated and likely effective treatment option in the community setting. Further large prospective controlled trials are still needed.

Keywords: Fibromyalgia, low dose naltrexone, fatigue, CAMs, treatment, endorphin function.

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Article Details

Year: 2018
Published on: 06 July, 2018
Page: [177 - 180]
Pages: 4
DOI: 10.2174/1573397113666170321120329
Price: $65

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