Berberine Derivatives with Different Pharmacological Activities via Structural Modifications

Author(s): Daipeng Xiao, Zhenbao Liu, Shanshan Zhang, Mi Zhou, Fen He, Ming Zou, Junying Peng, Xiong Xie, Yanfei Liu*, Dongming Peng*.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 18 , Issue 17 , 2018

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Graphical Abstract:


Berberine, a quaternary ammonium protoberberine alkaloid with an isoquinoline scaffold isolated from medicinal herbs, exhibits a wide spectrum of pharmacological activities. Berberine has been used in traditional Chinese medicine and Ayurvedic medicine. However, it has poor bioavailability, which seriously limits its application and development. The chemical transformation of natural products is an effective method to improve pharmacological activities. Researches have been carried out on the modification of berberine to obtain better pharmacological properties. In this paper, the structural modifications of berberine for different biological activities and its underlying mechanisms are reviewed.

Keywords: Berberine, bioavailability, chemical transformation, mechanisms, pharmacological activities, structural modification.

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Article Details

Year: 2018
Page: [1424 - 1441]
Pages: 18
DOI: 10.2174/1389557517666170321103139
Price: $65

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