Current Developments in Stroke

Current Developments in Stroke

Volume: 1

New Concepts in Stroke Diagnosis and Therapy

This volume presents a summary of recent research and debates on old and new aspects in stroke medicine. The volume covers topics such as causative factors of stroke such as hypertension, the immune ...
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On the Influence of Normalization Strategies for Perfusion MRI in Acute Stroke

Pp. 176-190 (15)

DOI: 10.2174/9781681084213117010011

Author(s): Mathilde Giacalone, Carole Frindel, Robin Zagala, Tae-Hee Cho, Yves Berthezène, Norbert Nighoghossian, David Rousseau


Normalization of magnetic resonance images with a given reference is a common preprocessing task which is rarely discussed. We review and address this question for a specific neuro-imaging problem of practical huge interest. We investigate the influence of the location of region of interest used for normalization of perfusion maps obtained with perfusion magnetic resonance imaging in the framework of the study of acute stroke. We demonstrate that a slice by slice normalization based on the whole hemisphere strategy optimally reduces the variability of the predictive value of the different perfusion maps. Interestingly, this is obtained for all the tested perfusion maps both from numerical simulation of perfusion MRI and from perfusion maps of real patients through a Neyman-Pearson detection strategy. These are important results to ease the quantitative assessment of stroke lesion from perfusion MRI on cohorts of patients. The proposed methodology could easily be transposed to other medical imaging problems where normalization of images is necessary.


Acute stroke, Image processing, Ischemic penumbra, Ischemic stroke, Medical Imaging, MRI, Neuroimaging, Normalization, Perfusion maps, Perfusion MRI.