Context: Oral disintegrating tablets (ODTs) represent a better option than conventional tablets
for geriatric population, owing to their fast onset of action and their better patient compliance.
Objective: Two principal therapeutic high-dose nutraceuticals; chondroitin sulphate and glucosamine
were formulated into an oral disintegration tablet (ODT) intended for sublingual administration, and
optimized to improve compliance and achieve rapid onset of action in osteoarthritis treatment.
Materials and Methods: Different formulations were prepared either by melt granulation or direct
compression techniques. Excipients at different ratios such as superdisintegrants, pharmaburst™ C1,
spray-dried mannitol, and polyethylene glycols were used to enhance the disintegration time for the
Results: Although the ODT systems weighed around 1.3 gm with 60% drug load, some systems disintegrated
within 2-3 min with 100% drug release. Pharmaburst™ C1 turned out to be the key excipient
responsible for the superdisintegration properties of the ODTs. Dissolution enhancement of the two nutraceuticals
could be achieved compared to the marketed conventional tablets.
Conclusion: The improved disintegration and dissolution properties of our prepared ODTs are expected
to enhance the bioavailability of the high dose glucosamine and chondroitin sulphate in comparison
with conventional tablets, which delineates them as a promising dosage form for the aforementioned