Title:Medicinal Plants as Protective Strategies Against Parkinson's Disease
VOLUME: 23 ISSUE: 28
Author(s):Natalia Areiza Mazo, Valentina Echeverria*, Ricardo Cabezas, Marco Avila-Rodriguez, Vadim V. Tarasov, Nagendra S. Yarla, Gjumrakch Aliev and George E. Barreto
Affiliation:Departamento de Nutricion y Bioquimica, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogota D.C, Universidad San Sebastian, Lientur 1457, Concepcion, 4030000, Departamento de Nutricion y Bioquimica, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogota D.C, Departamento de Nutricion y Bioquimica, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogota D.C, Institute of Pharmacy and Translational Medicine, Sechenov First Moscow State Medical University, 2-4 Bolshaya Pirogovskaya St., 119991 Moscow, Department of Biochemistry and Bioinformatics, Institute of Science, GITAM University, Visakhapatnam-530 045, Andhra Pradesh, GALLY International Biomedical Research Consulting LLC, San Antonio, TX, Departamento de Nutricion y Bioquimica, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogota D.C
Keywords:Parkinson's Disease, phytochemicals, neuroprotective fruits, signaling pathways, transcription factors, dopaminergic neurons.
Abstract:Parkinson's disease is a neurodegenerative disease caused by the loss of dopaminergic neurons in the
substantia nigra pars compacta region. An important mechanism contributing to its development is oxidative
stress, induced by the imbalance between the endogenous antioxidant defenses and free radicals production. Naturally
occurring bioactive compounds exhibit high antioxidant capacity that may help reducing oxidative stress and
even reverse the damage induced by ROS. Fruits are particularly rich in phytochemicals with antioxidant effect,
and their properties against the development of neurodegenerative diseases are of great interest. This review discusses
how the fruits bioactive compounds and synthetic analogs have been assessed for their ability to regulate
molecular pathways involved in neuronal survival such as MAPK, Nrf2, and NF-κB, thus elucidating the possible
therapeutic and neuroprotective actions of these compounds.
