Background: Breast cancer is one of the high prevalence cancers worldwide
affecting women based on various factors. Hormonal changes are amongst the factors
involved in the development of breast cancer. The basic hormones involved include estrogen
and progesterone with human epidermal receptor-2 (HER2) which could be either
over expressed or not at all expressed. Therefore, studies were conducted on the DMBA
induced breast cancer model.
Methods: As per literature review, there has been complete befuddlement on the hormonal
crisis of the DMBA induced model hence we performed the immunohistochemistry
studies of estrogen, progesterone and human epidermal receptor-2 in order to prove the
presence or absence of the major hormones involved in progression of breast cancer.
Preceding morphological tumor detection, it was further confirmed with hematoxylineosin
Results: These data initially detected the probable presence of mucin in the hematoxylin-
eosin stain hence we performed specific mucin stain using Meyer’s mucincarmine
concluding mucinous carcinoma. Thereafter, we obtained negative estrogen and HER2,
with positive progesterone in the immunohistochemistry studies.
Conclusion: Conclusively, DMBA induced breast cancer is a suitable model for mucinous
carcinoma in estrogen and human epidermal receptor-2 negative and progesterone
positive breast cancer.