Background: Neural stem/progenitor cells (NSPCs)-based treatment is a potential therapeutic approach
for stroke. MicroRNAs (miRNAs) have been recently verified as promoters or suppressors in the regulation
of NSPCs. However, the underlying mechanisms regulating cell biological behaviors of NSPCs remain
Methods: we retrieved papers focusing on potential roles and mechanisms of miRNAs in the regulation of
NSPCs, and paid a special attention to clinical therapeutic potentials of miRNAs in stroke patients. This narrative
review provides a comprehensive and critical landscape of this issue.
Results: We summarize the most recent studies on the roles and mechanisms of miRNAs in regulating the proliferation,
differentiation and migration of NSPCs and fully discuss the potential clinical implications of miRNAs
interacting with NSPCs in stroke patients.
Conclusion: Promising but full of hurdles, miRNAs have been confirmed to play a critical role in regulating
NSPCs. Clinical potentials of miRNAs are huge in treating stroke patients receiving NSPCs-based therapy, which
can be used as biomarkers for the diagnosis and prognosis, and as targets for controlling the proliferation, differentiation
and migration of NSPCs.