In recent years, a drastic rise has been observed in incidences of resistance, low efficacy
rates and toxicities to various drugs used in therapeutic application. Presence of imidazole nucleus in
several categories of therapeutic agents such as anti-microbials, anti-virals, anti-cancer, etc has made it
a vital anchor for the development of new therapeutic agents. Still, there is a need to couple the newest
information with the already available knowledge to recognize the present standing of imidazole motif
in medicinal chemistry research. In the present review, importance of this nucleus in some less explored
activities like anti-malarial and anthelmintic is mentioned along with well explored fields like
cancer. Substitution pattern around imidazole nucleus is discussed here with an aim to help medicinal
chemists for the development of SAR of imidazole based compounds for each activity. This discussion
will further help in the advancement of existing imidazole derivatives and in the generation of new and
safe imidazole compounds.
Keywords: Anti-cancer, antimicrobial, biological activities, drug development, heterocycles, imidazole.
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