Cyclic peptides, owing to their good stability, high resistance to exo- and to some extent
endo-peptidases, enhanced binding affinity and selectivity towards target biomolecules, are actively
investigated as biochemical tools and therapeutic agents. In this review, we discuss various commonly
utilized synthetic strategies for cyclic peptides and peptoids (peptidomimetics), their important
screening methods to identify the bioactive cyclic peptides and peptoids such as combinatorial beadbased
peptide library, phage display, mRNA display etc. and recent advances in their applications as
bioactive compounds. Lastly, we also make a summary and provide an outlook of the research area.