Background: Dihydrofurocoumarins are a large family of compounds, among them, dihydroangelicins
and dihydropsoralens, are present in various plant species with varied biological activity.
Several strategies have been developed for synthesizing these compounds and various catalysts
have been used for this purpose.
Methods: In this work, we report the synthesis of 8,9-dihydrofuran [2, 3-h] coumarins using allyloxycoumarin
cycloaddition in sustainable conditions: absence of solvents, application of microwave
radiation, and insoluble acid catalysis by means of heteropolyacids with Preyssler structure,
Conclusion: With these conditions, and testing sustainability by means of Eco-Scale and E-factor, we
replace the use of solvents and mineral acids having a great impact on the environment with a solid,
easily recoverable heteropolyacid.