Background: Corticotropin releasing hormone (CRH), the main peptide-mediator of stress,
has been found in the female reproductive system.
Objective: Herein, the role of CRH receptors in the female reproductive system is presented.
Results: It is clear that CRH receptors are involved in the regulation of the hypothalamic-pituitaryovarian
axis, while locally are associated with decidualization, embryonic implantation, early fetal development
and triggering of parturition.
Conclusion: Abnormal CRH signaling may contribute to obstetrical pathophysiology, such as preeclampsia,
abnormal placenta invasion, endometrial growth retardation and preterm delivery.