Synthesis and Anticancer Studies of Novel N-benzyl Pyridazino ne Derivatives

Author(s): Mohamed Elagawany, Mohamed A. Ibrahim, Tarek S. Ibrahim, Amany M.M. AL-Mahmoudy, Alaa Moawad, Mohammed M. Ghoneim, Mohamed M. Radwan, Siva S. Panda*

Journal Name: Letters in Drug Design & Discovery

Volume 14 , Issue 9 , 2017

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Abstract:

Introduction: According to WHO, cancer is one of the most leading causes of death. Development of anticancer drugs draw considerable attention. Pyridazinones analogues were reported to possess anticancer properties. Chemical modification of pyridazinone may lead to potential anticancer agent.

Objective: The objective of this article is to develop new pyridazinone deriatives and evaluate their anticancer activities.

Results: The target compounds were synthesized using Palladium cross coupling reactions, Buchwald and Suzuki, the synthesized compound were evaluated against BT-549, KB and SK-MEL cell lines. Some compounds showed moderate to significant inhibitory activity.

Conclusion: Novel pyridazinone derivatives were synthesized in a good yield. Some of the synthesized analogues showed good anticancer properties against BT-549, KB and SK-MEL cell lines.

Keywords: Anticancer, pyridazinone, suzuki, buwald coupling, anti-inflammatory, cardiovascular activities.

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Article Details

VOLUME: 14
ISSUE: 9
Year: 2017
Page: [1008 - 1013]
Pages: 6
DOI: 10.2174/1570180814666170223111312
Price: $65

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