Introduction: According to WHO, cancer is one of the most leading causes of death.
Development of anticancer drugs draw considerable attention. Pyridazinones analogues were reported
to possess anticancer properties. Chemical modification of pyridazinone may lead to potential
Objective: The objective of this article is to develop new pyridazinone deriatives and evaluate their
Results: The target compounds were synthesized using Palladium cross coupling reactions, Buchwald
and Suzuki, the synthesized compound were evaluated against BT-549, KB and SK-MEL cell lines.
Some compounds showed moderate to significant inhibitory activity.
Conclusion: Novel pyridazinone derivatives were synthesized in a good yield. Some of the synthesized
analogues showed good anticancer properties against BT-549, KB and SK-MEL cell lines.