Abstract
Introduction: According to WHO, cancer is one of the most leading causes of death. Development of anticancer drugs draw considerable attention. Pyridazinones analogues were reported to possess anticancer properties. Chemical modification of pyridazinone may lead to potential anticancer agent.
Objective: The objective of this article is to develop new pyridazinone deriatives and evaluate their anticancer activities. Results: The target compounds were synthesized using Palladium cross coupling reactions, Buchwald and Suzuki, the synthesized compound were evaluated against BT-549, KB and SK-MEL cell lines. Some compounds showed moderate to significant inhibitory activity. Conclusion: Novel pyridazinone derivatives were synthesized in a good yield. Some of the synthesized analogues showed good anticancer properties against BT-549, KB and SK-MEL cell lines.Keywords: Anticancer, pyridazinone, suzuki, buwald coupling, anti-inflammatory, cardiovascular activities.
Graphical Abstract
Related Journals
Anti-Cancer Agents in Medicinal Chemistry
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
Current Computer-Aided Drug Design
Current Bioactive Compounds
Current Cancer Drug Targets
Combinatorial Chemistry & High Throughput Screening
Current Cancer Therapy Reviews
Current Diabetes Reviews
Current Drug Safety
Current Drug Targets
Related Books
Drug Addiction Mechanisms in the Brain
Software and Programming Tools in Pharmaceutical Research
Objective Pharmaceutics: A Comprehensive Compilation of Questions and Answers for Pharmaceutics Exam Prep
Medicinal Chemistry of Drugs Affecting Cardiovascular and Endocrine Systems
Medicinal Plants, Phytomedicines and Traditional Herbal Remedies for Drug Discovery and Development against COVID-19
Advanced Pharmacy
Plant-derived Hepatoprotective Drugs
The Role of Chromenes in Drug Discovery and Development
New Avenues in Drug Discovery and Bioactive Natural Products
Practice and Re-Emergence of Herbal Medicine
45
2